CAS 1189671-48-4

Etravirine-13C3

Description:

Etravirine-13C3 is a labeled analog of Etravirine, an antiretroviral medication used primarily in the treatment of HIV infection. The "13C3" designation indicates that three carbon atoms in the molecule are isotopically labeled with carbon-13, a stable isotope of carbon. This labeling is often utilized in research and clinical studies to trace metabolic pathways or to improve the understanding of drug interactions and pharmacokinetics. Etravirine itself is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that works by inhibiting the reverse transcriptase enzyme, which is crucial for the replication of HIV. The compound is characterized by its ability to maintain efficacy against HIV strains resistant to other NNRTIs, making it a valuable option in antiretroviral therapy. Its chemical structure includes various functional groups that contribute to its pharmacological properties, and it is typically administered orally. As with any pharmaceutical compound, safety, efficacy, and potential side effects are important considerations in its use.

Formula: C₂₀H₁₅BrN₆O

Synonyms:

• 4-[[6-Amino-5-bromo-2-[(4-cyanophenyl)amino]-4-pyrimidinyl-13C3]oxy]-3,5-dimethyl -benzonitrile
• R 165335-13C3
• -
• TMC 125-13C3
• 4-[[6-AMino-5-broMo-2-[(4-cyanophenyl)aMino]-4-pyriMidinyl-13C3]oxy]-3,5-diMethyl
• Etravirine-13C3

Etravirine-13C3

Controlled Product

CAS: 1189671-48-4

Applications A novel labelled HIV reverse transcriptase inhibitor useful in treatment of HIV infection.
References Scholler-Gyure, M., et al.: J. Clin. Pharmacol., 48, 322 (2008), Thakur, A., et al.: Eur. J. Med. Chem., 43, 471 (2008),

Formula: C₁₇₁₃C₃H₁₅BrN₆O

Color and Shape: Neat

Molecular weight: 438.25

Ref: TR-E937002