CAS 118974-02-0

Fumitremorgin C

Description:

Fumitremorgin C is a naturally occurring alkaloid that belongs to the class of compounds known as tremorgenic mycotoxins, which are produced by certain fungi, particularly species of Aspergillus and Penicillium. This compound is characterized by its complex polycyclic structure, which includes multiple rings and functional groups that contribute to its biological activity. Fumitremorgin C has been studied for its potential pharmacological properties, including its effects on the central nervous system and its ability to inhibit certain enzymes, such as protein phosphatases. It exhibits a range of biological activities, including neurotoxic effects, which can lead to tremors and other neurological symptoms in affected organisms. The compound's mechanism of action is thought to involve interference with neurotransmitter signaling pathways. Due to its toxic nature, fumitremorgin C is of interest in both toxicology and pharmacology, prompting research into its effects and potential applications, as well as the need for safety assessments in environments where it may be encountered.

Formula: C₂₂H₂₅N₃O₃

InChI: InChI=1S/C22H25N3O3/c1-12(2)9-18-20-15(14-7-6-13(28-3)10-16(14)23-20)11-19-21(26)24-8-4-5-17(24)22(27)25(18)19/h6-7,9-10,17-19,23H,4-5,8,11H2,1-3H3/t17-,18-,19-/m0/s1

InChI key: InChIKey=DBEYVIGIPJSTOR-FHWLQOOXSA-N

SMILES: C(=C(C)C)[C@@H]1N2[C@@](CC3=C1NC=4C3=CC=C(OC)C4)(C(=O)N5[C@](C2=O)(CCC5)[H])[H]

Synonyms:

• (5aS,12S,14aS)-1,2,3,5a,6,11,12,14a-Octahydro-9-methoxy-12-(2-methyl-1-propen-1-yl)-5H,14H-pyrrolo[1′′,2′′:4′,5′]pyrazino[1′,2′:1,6]pyrido[3,4-b]indole-5,14-dione
• 12α-Fumitremorgin C
• 5H,14H-Pyrrolo[1′′,2′′:4′,5′]pyrazino[1′,2′:1,6]pyrido[3,4-b]indole-5,14-dione, 1,2,3,5a,6,11,12,14a-octahydro-9-methoxy-12-(2-methyl-1-propen-1-yl)-, (5aS,12S,14aS)-
• 5H,14H-Pyrrolo[1′′,2′′:4′,5′]pyrazino[1′,2′:1,6]pyrido[3,4-b]indole-5,14-dione, 1,2,3,5a,6,11,12,14a-octahydro-9-methoxy-12-(2-methyl-1-propenyl)-, (5aS,12S,14aS)-
• 5H,14H-Pyrrolo[1′′,2′′:4′,5′]pyrazino[1′,2′:1,6]pyrido[3,4-b]indole-5,14-dione, 1,2,3,5a,6,11,12,14a-octahydro-9-methoxy-12-(2-methyl-1-propenyl)-, [5aS-(5aα,12β,14aα)]-
• 5H,14H-pyrrolo[1'',2'':4',5']pyrazino[1',2':1,6]pyrido[3,4-b]indole-5,14-dione, 1,2,3,5a,6,11,12,14a-octahydro-9-methoxy-12-(2-methyl-1-propen-1-yl)-, (5aS,12S,14aS)-
• Fumitremorgin C

Fumitremorgin C

CAS: 118974-02-0

Formula: C₂₂H₂₅N₃O₃

Purity: 95%

Color and Shape: Solid

Molecular weight: 379.4522

Ref: IN-DA008Y1Y

Fumitremorgin C

CAS: 118974-02-0

Fumitremorgin C (12α-Fumitremorgin C) is a mycotoxin and inhibits ABCG2/BRCP.

Formula: C₂₂H₂₅N₃O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 379.45

Ref: TM-T15355

Fumitremorgin C

CAS: 118974-02-0

Fumitremorgin C

Color and Shape: Tan Solid

Molecular weight: 379.45g/mol

Ref: 54-BIF1010

Fumitremorgin C

CAS: 118974-02-0

Formula: C₂₂H₂₅N₃O₃

Purity: 95%~99%

Molecular weight: 379.46

Ref: BP-SBP04247

Fumitremorgin C

CAS: 118974-02-0

Formula: C₂₂H₂₅N₃O₃

Molecular weight: 379.45

Ref: 7W-GA2954

Fumitremorgin C

CAS: 118974-02-0

Inhibitor of BCRP transporter; inhibitor of multidrug resistance

Purity: Min. 95%

Ref: 3D-BF162727

Fumitremorgin C

Controlled Product

CAS: 118974-02-0

Applications Fumitremorgin C is a tremorgenic mycotoxin isolated from Aspergillus fumigatus. Recent research has determined fumitremorgin C as a potent inhibitor of the breast cancer resistance protein BCRP/ABCG2 multidrug transporter.
References Allen, J.D., et al.: Mol. Cancer. Ther., 1, 417 (2002); Jakub, H., et al.: Pharmacol. Res., 65, 312 (2012); Shen, B., et al.: Exp. Ther. Med., 2, 1151 (2011);

Formula: C₂₂H₂₅N₃O₃

Color and Shape: Neat

Molecular weight: 379.45

Ref: TR-F862680