CAS 1189916-55-9

O-Desmethyl Indomethacin-d4

Description:

O-Desmethyl Indomethacin-d4 is a deuterated derivative of Indomethacin, a nonsteroidal anti-inflammatory drug (NSAID) commonly used to relieve pain, swelling, and inflammation. The "O-Desmethyl" designation indicates that this compound is a demethylated form of Indomethacin, specifically lacking a methyl group at the oxygen position. The "d4" notation signifies that four hydrogen atoms in the molecule have been replaced with deuterium, a stable isotope of hydrogen, which is often used in research to trace metabolic pathways or improve analytical detection methods. This compound is typically utilized in pharmacokinetic studies and drug metabolism research due to its isotopic labeling. O-Desmethyl Indomethacin-d4 retains the core structure and pharmacological properties of Indomethacin, making it relevant for studies focused on the drug's efficacy and safety profiles. Its unique isotopic composition allows for precise quantification and tracking in biological systems, enhancing the understanding of drug behavior in vivo.

Formula: C₁₈H₁₄ClNO₄

Synonyms:

• indoMethacin-d4
• [2H4]-O-Desmethyl Indomethacin
• DesMethylindoMethacin-d4
• O-Desmethyl Indomethacin-d4
• 1-(4-Chlorobenzoyl-d4)-5-hydroxy-2-Methyl-1H-indole-3-acetic Acid
• 5-Hydroxy-
• DeMethylindoMethacin-d4

O-Desmethyl Indomethacin-d4

CAS: 1189916-55-9

Formula: C₁₈H₁₀D₄ClNO₄

Molecular weight: 347.79

Ref: 4Z-I-1241

O-Desmethyl Indomethacin-d4

Controlled Product

CAS: 1189916-55-9

Applications The major labelled metabolite of Indomethacin.
References Lewis, R., et al.: J. Clin. Invest., 53, 1607 (1974), Alvan, G., et al.: Clin. Pharmacol. Ther., 18, 364 (1975), Mungall, D., et al.: J. Pharm. Sci., 73, 1000 (1984), Baldwin, S., et al.: Xenobiotica, 25, 261 (1995),

Formula: C₁₈H₁₀D₄ClNO₄

Color and Shape: Neat

Molecular weight: 347.79

Ref: TR-D291802