CAS 1189923-43-0

Trazodone EP Impurity L-d8 DiHCl

CAS: 1189923-43-0

Formula: C₁₀H₅D₈ClN₂·2HCl

Color and Shape: Off-White Solid

Molecular weight: 204.73 2*36.46

Ref: 4Z-T-3320

1-(3-Chlorophenyl)piperazine-d8

Controlled Product

CAS: 1189923-43-0

Applications It is noteworthy that 1-(3-Chlorphenyl)piperazine (m-CPP), resulting from N-dealkylation of Trazodone, is a major circulating metabolite in humans common to several antidepressants including Trazodone, Nefazodone, and Etoperidone. The metabolite m-CPP is of significant interest because it has 5-HT2C agonistic and 5-HT2A antagonistic properties. It has also been suggested that m-CPP may contribute to the antidepressant efficacy of Trazodone.
References Melzacka, M., et al.: Pol. J. Pharmacol Pharm., 32, 551 (1980), Fong, M.H., et al.: J. Pharm. Pharmacol., 34, 674 (1982), Fiorella, D., et al.: Psychopharmacology, 119, 220 (1995), Maes, M., et al.: J. Clin. Psychopharmacol., 17, 358 (1997), Bo Wen, et al.: Drug Metab. Dispos., 36, 841 (2008),

Formula: C₁₀H₅D₈ClN₂

Color and Shape: Neat

Molecular weight: 204.73

Ref: TR-C379592

1-(3-Chlorophenyl)piperazine-d8

Controlled Product

CAS: 1189923-43-0

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Formula: C₁₀H₁₃ClN₂

Purity: Min. 95%

Molecular weight: 204.72 g/mol

Ref: 3D-PXB92343