Dendrotoxin K is a neurotoxic protein primarily derived from the venom of certain species of mamba snakes, particularly the black mamba (Dendroaspis polylepis). It is classified as a three-finger toxin, a family of proteins known for their characteristic structural motif. Dendrotoxin K functions by blocking voltage-gated potassium channels, which disrupts neuronal excitability and can lead to paralysis or other neurological effects. This mechanism of action makes it a subject of interest in neurobiology and pharmacology, as it can provide insights into ion channel function and potential therapeutic applications. The protein is composed of a specific sequence of amino acids that contribute to its stability and binding affinity to target channels. Dendrotoxin K is also notable for its relatively high toxicity, which underscores the evolutionary adaptations of venomous snakes for predation and defense. Research into dendrotoxins continues to explore their potential uses in medicine, particularly in pain management and the treatment of neurological disorders.

dendrotoxin K

119128-61-9: Dendrotoxin K is a neurotoxic protein primarily derived from the venom of certain species of mamba snakes, particularly the black mamba (Dendroaspis polylepis). It is classified as a three-finger toxin, a family of proteins known for their characteristic structural motif. Dendrotoxin K functions by blocking voltage-gated potassium channels, which disrupts neuronal excitability and can lead to paralysis or other neurological effects. This mechanism of action makes it a subject of interest in neurobiology and pharmacology, as it can provide insights into ion channel function and potential therapeutic applications. The protein is composed of a specific sequence of amino acids that contribute to its stability and binding affinity to target channels. Dendrotoxin K is also notable for its relatively high toxicity, which underscores the evolutionary adaptations of venomous snakes for predation and defense. Research into dendrotoxins continues to explore their potential uses in medicine, particularly in pain management and the treatment of neurological disorders.

<p>Dendrotoxin K blocks Kv1.1 channels, modulating glutamate release in CA3 neurons by controlling presynaptic spike timing.</p>

CAS 119128-61-9

dendrotoxin K

Dendrotoxin K

Ref: TM-T76187