CAS 1192500-31-4

Avibactam

Description:

Avibactam is a synthetic β-lactamase inhibitor that is primarily used in combination with certain antibiotics to enhance their efficacy against resistant bacterial strains. It is particularly effective against a range of β-lactamases, including class A and some class C enzymes, which are responsible for antibiotic resistance. Avibactam is characterized by its unique bicyclic structure, which contributes to its stability and ability to inhibit β-lactamases. The compound is typically administered intravenously and is known for its favorable pharmacokinetic properties, including good tissue penetration and a relatively long half-life. Avibactam is often combined with cephalosporins, such as ceftazidime, to treat complicated infections caused by multidrug-resistant Gram-negative bacteria. Its development represents a significant advancement in the fight against antibiotic resistance, as it restores the activity of β-lactam antibiotics that would otherwise be ineffective due to enzymatic degradation. Overall, Avibactam plays a crucial role in modern antimicrobial therapy, particularly in hospital settings where resistant infections are prevalent.

Formula: C₇H₁₁N₃O₆S

InChI: InChI=1S/C7H11N3O6S/c8-6(11)5-2-1-4-3-9(5)7(12)10(4)16-17(13,14)15/h4-5H,1-3H2,(H2,8,11)(H,13,14,15)/t4-,5+/m1/s1

InChI key: InChIKey=NDCUAPJVLWFHHB-UHNVWZDZSA-N

SMILES: C(N)(=O)[C@H]1[N@@]2C(=O)N(OS(=O)(=O)O)[C@@](C2)(CC1)[H]

Synonyms:

• Avibactam
• Sulfuric acid mono[(1R,2S,5R)-2-(aminocarbonyl)-7-oxo-1,6-diazabicyclo[3.2.1]oct-6-yl] ester
• Trans-7-Oxo-6-(Sulphooxy)-1,6-Diazabicyclo[3.2.1]Octane-2-Carboxamide

Avibactam

CAS: 1192500-31-4

Formula: C₇H₁₁N₃O₆S

Purity: 98%

Molecular weight: 265.2437

Ref: IN-DA008TDM

(1R,2S,5R)-2-Carbamoyl-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl hydrogen sulfate

CAS: 1192500-31-4

(1R,2S,5R)-2-Carbamoyl-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl hydrogen sulfate

Purity: 98%

Molecular weight: 265.25g/mol

Ref: 54-OR1068231

Avibactam free acid

CAS: 1192500-31-4

Avibactam free acid is a potent β-lactamase inhibitor exhibiting covalent and reversible properties, capable of inhibiting TEM-1, P99, and CTX-M-15.

Formula: C₇H₁₁N₃O₆S

Purity: 99.17%

Color and Shape: Solid

Molecular weight: 265.24

Ref: TM-T10422

Avibactam free acid

CAS: 1192500-31-4

Avibactam free acid is a β-lactamase inhibitor and is used for the treatment of bacterial infections in combination with β-lactam antibiotics. It inactivates β-lactamases by a covalent and reversible mechanism

Formula: C₇H₁₁N₃O₆S

Purity: Min. 95 Area-%

Color and Shape: Powder

Molecular weight: 265.24 g/mol

Ref: 3D-AA158833

Avibactam Butylammonium Salt

Controlled Product

CAS: 1192500-31-4

Applications Avibactam Butylammonium Salt is a novel β-lactamase inhibitor with a non-lactam structural scaffold. Avibactam irreversibly inhibits lactamase from Mycobacterium tuberculosis.
References Iland, C., et al.: J. Pathol. Bacteriol., 58, 495 (1946); Flores, A., et al.: Microbiology, 151, 521 (2005); Livermore, D., et al.: J. Antimicrob. Chemother., 62, 1053 (2008); Tremblay, L., et al.: Biochemistry, 49, 9685 (2010)

Formula: C₇H₁₀N₃O₆S·C₄H₁₂N

Color and Shape: Neat

Molecular weight: 338.381

Ref: TR-A794845