The chemical substance known as "(1S,2R,4S)-N-(ISOQUINOLIN-3-YL)-4H-4-AZASPIRO[BICYCLO[2.2.2]OCTANE-2,5-OXAZOL]-2-AMINE" with CAS number 1192810-88-0 is characterized by its complex bicyclic structure, which incorporates both azaspiro and oxazole functionalities. This compound features a chiral center, indicated by the stereochemical descriptors (1S,2R,4S), suggesting specific spatial arrangements of its atoms that can influence its biological activity and interactions. The presence of the isoquinoline moiety may contribute to its pharmacological properties, as isoquinolines are often associated with various biological activities. Additionally, the azaspiro structure can enhance the compound's rigidity and may affect its binding affinity to biological targets. The amine group indicates potential for hydrogen bonding, which can be crucial for solubility and reactivity. Overall, this compound's unique structural features suggest it may be of interest in medicinal chemistry, particularly in the development of novel therapeutic agents.

BMS-902483 is a potent α7 partial agonist, which improved cognition in preclinical rodent models. BMS-902483 showed FLIR α7 EC50=9.3nM; α7 Electrophysiology, rat; Area EC50 = 140 nM; Peak, Area (Ymax %) = 40, 54. 5-HT3A IC50 = 480 nm. Preclinical and early clinical data suggest that α7 nicotinic acetylcholine receptor (nAChR) agonists have potential for the treatment of cognitive and negative symptoms in schizophrenia patients

(1S,2R,4S)-N-(ISOQUINOLIN-3-YL)-4H-4-AZASPIRO[BICYCLO[2.2.2]OCTANE-2,5-OXAZOL]-2-AMINE

1192810-88-0: The chemical substance known as "(1S,2R,4S)-N-(ISOQUINOLIN-3-YL)-4H-4-AZASPIRO[BICYCLO[2.2.2]OCTANE-2,5-OXAZOL]-2-AMINE" with CAS number 1192810-88-0 is characterized by its complex bicyclic structure, which incorporates both azaspiro and oxazole functionalities. This compound features a chiral center, indicated by the stereochemical descriptors (1S,2R,4S), suggesting specific spatial arrangements of its atoms that can influence its biological activity and interactions. The presence of the isoquinoline moiety may contribute to its pharmacological properties, as isoquinolines are often associated with various biological activities. Additionally, the azaspiro structure can enhance the compound's rigidity and may affect its binding affinity to biological targets. The amine group indicates potential for hydrogen bonding, which can be crucial for solubility and reactivity. Overall, this compound's unique structural features suggest it may be of interest in medicinal chemistry, particularly in the development of novel therapeutic agents.

<p>BMS-902483: potent α7 partial agonist; enhances rodent cognition; α7 EC50=9.3nM; 5-HT3A IC50=480nM.</p>

CAS 1192810-88-0

(1S,2R,4S)-N-(ISOQUINOLIN-3-YL)-4H-4-AZASPIRO[BICYCLO[2.2.2]OCTANE-2,5-OXAZOL]-2-AMINE

BMS-902483

Ref: TM-T26862