CAS 1193314-23-6

Cipargamin

Description:

Cipargamin, with the CAS number 1193314-23-6, is a novel antimalarial compound that belongs to the class of spiroindolones. It exhibits a unique mechanism of action by inhibiting the Plasmodium falciparum parasite's ability to replicate within red blood cells. This compound has shown promising efficacy against various strains of malaria, including those resistant to existing treatments. Cipargamin is characterized by its high potency and selectivity, which minimizes off-target effects and potential toxicity. Its pharmacokinetic profile suggests favorable absorption and distribution characteristics, making it a candidate for oral administration. Additionally, ongoing research is focused on understanding its safety profile and potential for combination therapies to enhance treatment outcomes. As a part of the ongoing efforts to combat malaria, Cipargamin represents a significant advancement in the search for effective antimalarial agents, particularly in the face of rising drug resistance.

Formula: C₁₉H₁₄Cl₂FN₃O

InChI: InChI=1S/C19H14Cl2FN3O/c1-8-4-11-10-6-14(22)13(21)7-16(10)23-17(11)19(25-8)12-5-9(20)2-3-15(12)24-18(19)26/h2-3,5-8,23,25H,4H2,1H3,(H,24,26)/t8-,19+/m0/s1

InChI key: InChIKey=CKLPLPZSUQEDRT-WPCRTTGESA-N

SMILES: O=C1[C@]2(C3=C(C=4C(N3)=CC(Cl)=C(F)C4)C[C@H](C)N2)C=5C(N1)=CC=C(Cl)C5

Synonyms:

• (1′R,3′S)-5,7′-Dichloro-6′-fluoro-2′,3′,4′,9′-tetrahydro-3′-methylspiro[3H-indole-3,1′-[1H]pyrido[3,4-b]indol]-2(1H)-one
• Cipargamin
• Kae 609
• Nitd 609
• Spiro[3H-indole-3,1′-[1H]pyrido[3,4-b]indol]-2(1H)-one, 5,7′-dichloro-6′-fluoro-2′,3′,4′,9′-tetrahydro-3′-methyl-, (1′R,3′S)-

Cipargamin

CAS: 1193314-23-6

Cipargamin (NITD609) is an effective antimalarial compound. It has an IC50 of appr 1 nM against P. falciparum.

Formula: C₁₉H₁₄Cl₂FN₃O

Purity: 99.9%

Color and Shape: Solid

Molecular weight: 390.24

Ref: TM-T16326

Spiro[3h-indole-3,1'-[1h]pyrido[3,4-b]indol]-2(1h)-one, 5,7'-dichloro-6'-fluoro-2',3',4',9'-tetrahydro-3'-methyl-, (1'r,3's)-

CAS: 1193314-23-6

Formula: C₁₉H₁₄Cl₂FN₃O

Purity: 97%

Color and Shape: Solid

Molecular weight: 390.2384

Ref: IN-DA000IMA

Cipargamin

CAS: 1193314-23-6

Cipargamin

Purity: ≥98%

Molecular weight: 390.24g/mol

Ref: 54-BUP15301

Cipargamin

Controlled Product

CAS: 1193314-23-6

Formula: C₁₉H₁₄Cl₂FN₃O

Color and Shape: Neat

Molecular weight: 390.238

Ref: TR-C445780