CAS 119478-56-7

Meropenem trihydrate

Description:

Meropenem trihydrate is a broad-spectrum antibiotic belonging to the carbapenem class, primarily used to treat severe bacterial infections. It is characterized by its ability to inhibit bacterial cell wall synthesis, making it effective against a wide range of Gram-positive and Gram-negative bacteria, including those resistant to other antibiotics. The trihydrate form indicates that the compound contains three molecules of water per molecule of meropenem, which can influence its solubility and stability. Meropenem is typically administered via intravenous injection due to its poor oral bioavailability. It is known for its favorable pharmacokinetic properties, including a relatively long half-life and good tissue penetration. Common side effects may include gastrointestinal disturbances, headache, and potential allergic reactions. As with other antibiotics, the emergence of resistance is a concern, necessitating careful use and adherence to prescribed regimens. Overall, meropenem trihydrate is a critical option in the treatment of serious infections, particularly in hospital settings.

Formula: C₁₇H₂₅N₃O₅S

InChI: InChI=1/C17H25N3O5S/c1-7-12-11(8(2)21)16(23)20(12)13(17(24)25)14(7)26-9-5-10(18-6-9)15(22)19(3)4/h7-12,18,21H,5-6H2,1-4H3,(H,24,25)/t7-,8+,9-,10-,11-,12-/m0/s1

InChI key: InChIKey=CTUAQTBUVLKNDJ-OBZXMJSBSA-N

SMILES: C(O)(=O)C=1N2[C@@]([C@@]([C@@H](C)O)(C2=O)[H])([C@@H](C)C1S[C@H]3C[C@@H](C(N(C)C)=O)NC3)[H].O

Synonyms:

• (4R,5S,6S)-3-[[(3S,5S)-5-(Dimethylcarbamoyl)-3-pyrrolidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid trihydrate
• (4R,5S,6S)-3-[[(3S,5S)-5-(Dimethylcarbamoyl)pyrrolidin-3-yl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
• (4R,5S,6S)-3-{[(2S,5S)-5-(dimethylcarbamoyl)pyrrolidin-2-yl]sulfanyl}-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
• (4R,5S,6S)-3-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid trihydrate
• (4S,5R,6R)-3-[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl-6-(1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
• 1-Azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, 3-[[(3S,5S)-5-[(dimethylamino)carbonyl]-3-pyrrolidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-, hydrate (1:3), (4R,5S,6S)-
• 1-Azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, 3-[[(3S,5S)-5-[(dimethylamino)carbonyl]-3-pyrrolidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-, trihydrate, (4R,5S,6S)-
• 1-Azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, 3-[[5-[(dimethylamino)carbonyl]-3-pyrrolidinyl]thio]-6-(1-hydroxyethyl)-4-methyl-7-oxo-, trihydrate, [4R-[3(3S*,5S*),4α,5β,6β(R*)]]-
• Meropenem (with carbonate)
• Meropenem trihydrate
• Meropenem
• 3-[[5-[(Dimethylamino)carbonyl]-3-pyrrolidinyl]thio]-6-(1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3,2,0]hept-2-ene-2-carboxylic acid trihydrate
• 1-Azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, 3-[[5-[(dimethylamino)carbonyl]-3-pyrrolidinyl]thio]-6-(1-hydroxyethyl)-4-methyl-7-oxo-, trihydrate, [4R-[3(3S*,5S*),4a,5b,6b(R*)]]-(9CI)
• MEROPENEM WITH SODIUM CARBONATE
• MEROPENEM
• MEROPENEMTRIHYDRATE(3-[[5-[(DIMETHYLAMINO)CARBONYL]-3-PYRROLIDINYL]THIO]-6-(1-HYDROXYETHYL)-4-METHYL-7-OXO-1-AZABICYCLO[3,2,0]HEPT-2-ENE-2-CARBOXYLICACIDTRIHYDRATE)

Meropenem Trihydrate

CAS: 119478-56-7, 96036-03-2

Formula: C₁₇H₂₅N₃O₅S·3H₂O

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 437.51

Ref: 3B-M2279

Meropenem trihydrate, 98-101%

CAS: 119478-56-7

A broad spectrum antibiotic targeting a wide range of bacteria

Formula: C₁₇H₃₁N₃O₈S

Purity: 98-101%

Color and Shape: Powder or crystals or crystalline powder, White to pale yellow

Molecular weight: 437.51

Ref: 02-J66446

MEROPENEM TRIHYDRATE CRS

CAS: 119478-56-7

MEROPENEM TRIHYDRATE CRS

Formula: C₁₇H₂₅N₃O₅S

Color and Shape: Added Modified

Molecular weight: 383.4625

Ref: 41-Y0001252

Meropenem

CAS: 119478-56-7

Antibiotics nesoi

Formula: C₁₇H₂₅N₃O₅S·3H₂O

Color and Shape: White Light Yellow Powder

Molecular weight: 437.51

Ref: 45-1392454

(4R,5S,6S)-3-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid trihydrate

CAS: 119478-56-7

Formula: C₁₇H₃₁N₃O₈S

Purity: 97%

Color and Shape: Solid

Molecular weight: 437.5083

Ref: IN-DA000IV3

Meropenem trihydrate

CAS: 119478-56-7

Meropenem trihydrate (SM 7338 trihydrate) with broad-spectrum antibacterial activity,is a carbapenem antibiotic.

Formula: C₁₇H₃₁N₃O₈S

Purity: 99.80%

Color and Shape: Solid

Molecular weight: 437.51

Ref: TM-T12004

Meropenem trihydrate

CAS: 119478-56-7

Formula: C₁₇H₂₅N₃O₅S·3H₂O

Purity: ≥ 98.0% (anhydrous basis)

Color and Shape: White, off-white or faint beige crystalline powder

Molecular weight: 437.51

Ref: 7W-GP7412

Meropenem trihydrate, USP grade

CAS: 119478-56-7

Formula: C₁₇H₂₅N₃O₅S·3H₂O

Purity: ≤ 0.1% (anhydrous basis)

Color and Shape: White, off-white or faint beige crystalline powder

Molecular weight: 437.51

Ref: 7W-GP9211

Meropenem trihydrate

CAS: 119478-56-7

Meropenem trihydrate

Purity: ≥98%

Molecular weight: 437.51g/mol

Ref: 54-BUP15105

Meropenem trihydrate

Controlled Product

CAS: 119478-56-7

Formula: C₁₇H₂₅N₃O₅SH₂O

Color and Shape: Neat

Molecular weight: 437.51

Ref: 04-C14906000

Meropenem Trihydrate

CAS: 119478-56-7

Color and Shape: Neat

Ref: 86-MM1327.00

Meropenem RS

CAS: 119478-56-7

Color and Shape: White To Light Yellow Solid Crystalline Powder

Ref: 2K-7000960021

Meropenem Trihydrate

Controlled Product

CAS: 119478-56-7

Applications Meropenem Trihydrate is a carbapenem antibiotic with wide spectrum of antibacterial.
References Hickey, M.B., et al.: J. Pharma. Sci., 96, 1090 (2007); Condie, C.K., et al.: Am. J. Health. System. Pharma., 65, 454 (2008);

Formula: C₁₇H₂₅N₃O₅S·3H₂O

Color and Shape: Light Yellow

Molecular weight: 437.51

Ref: TR-M225640

Meropenem Trihydrate

CAS: 119478-56-7

Formula: C₁₇H₂₅N₃O₅S(H₂O)

Molecular weight: 383.5 : 3(18.0)

Ref: ST-EA-CP-M30000

Meropenem trihydrate

CAS: 119478-56-7

Inhibitor of cell-wall synthesis; carbapenem class

Formula: C₁₇H₂₅N₃O₅S·3H₂O

Purity: Min. 95 Area-%

Color and Shape: Powder

Molecular weight: 437.51 g/mol

Ref: 3D-AM16380

Meropenem trihydrate, Antibiotic for Culture Media Use Only

CAS: 119478-56-7

Meropenem trihydrate has broad spectrum activity against Gram-positive and Gram-negative bacteria, as well as, some mycoplasma species. It inhibits cell wall synthesis by binding to bacterial penicillin-binding proteins (PBP), which impairs cell wall integrity, induces the formation of reactive oxygen species, and inhibits macromolecular synthesis in bacteria. It can be used to prevent bacterial growth after being exposed to meropenem through fluorescence imaging of human blood plasma. Meropenem trihydrate research studies showed a reduction of the allergen levels in patients with respiratory allergies or asthma, specifically dust mites, cockroaches, animal dander, pollen grains, etc. by inhibit allergen-induced sensitization of mast cells.

Formula: C₁₇H₃₁N₃O₈S

Purity: Min. 98.0 Area-%

Molecular weight: 437.51 g/mol

Ref: 3D-M-2780

Meropenem trihydrate

CAS: 119478-56-7

Purity: 97%

Color and Shape: Solid

Molecular weight: 437.51

Ref: 10-F792074