CAS 1194961-19-7

PRT-060318

Description:

PRT-060318, with the CAS number 1194961-19-7, is a chemical compound that has garnered attention in the field of medicinal chemistry, particularly for its potential therapeutic applications. It is classified as a small molecule and is known to act as a selective inhibitor of certain protein kinases, which are crucial in various cellular signaling pathways. The compound's structure typically features specific functional groups that contribute to its biological activity and selectivity. PRT-060318 has been studied for its effects on cellular processes such as proliferation and apoptosis, making it a candidate for research in cancer treatment and other diseases characterized by dysregulated kinase activity. Its pharmacokinetic properties, including absorption, distribution, metabolism, and excretion (ADME), are essential for determining its viability as a therapeutic agent. Ongoing research aims to elucidate its mechanism of action and potential side effects, contributing to the broader understanding of kinase inhibitors in drug development.

5-Pyrimidinecarboxamide, 2-[[(1R,2S)-2-aminocyclohexyl]amino]-4-[(3-methylphenyl)amino]-

CAS: 1194961-19-7

Formula: C₁₈H₂₄N₆O

Purity: 99%

Color and Shape: Solid

Molecular weight: 340.4228

Ref: IN-DA000IVF

PRT-060318

CAS: 1194961-19-7

PRT-060318

Purity: ≥98%

Molecular weight: 340.42g/mol

Ref: 54-BUP01961

PRT-060318

CAS: 1194961-19-7

PRT-060318 (P142-76) is a novel selective inhibitor of the Syk tyrosine kinase, as an approach to HIT treatment.

Formula: C₁₈H₂₄N₆O

Purity: 99.98%

Color and Shape: Solid

Molecular weight: 340.42

Ref: TM-T6957

PRT-060318

CAS: 1194961-19-7

Ref: 7W-GW1561

PRT 060318

Controlled Product

CAS: 1194961-19-7

Applications PRT 060318 is a novel selective inhibitor of the tyrosine kinase Syk. PRT 060318 may be used in Heparin-Induced Thrombocytopenia (HIT) treatment. HIT is a major cause of morbidity and mortality.
References Reilly, M.P., et al.: Blood., 117, 2241 (2011)

Formula: C₁₈H₂₄N₆O

Color and Shape: Neat

Molecular weight: 340.42

Ref: TR-P838895

PRT 060318

CAS: 1194961-19-7

PRT 060318 is a small molecule that inhibits the expression of the protein Foxo1. It has been shown to inhibit the growth of chronic lymphocytic leukemia cells in culture, as well as inhibit their ability to migrate and invade other tissues. PRT 060318 also inhibits cell proliferation by blocking Annexin A2 signaling pathways. In vivo studies have shown that PRT 060318 can be used to suppress tumor growth and reduce the size of tumors in mice with a severe combined immunodeficiency (SCID) through inhibition of Foxo1. The drug does not appear to have any toxic effects on healthy cells and tissue, which may be due to its low affinity for Annexin A2.

Formula: C₁₈H₂₄N₆O

Purity: Min. 95%

Molecular weight: 340.42 g/mol

Ref: 3D-UXB96119