CAS 1195-08-0

5-formyluracil

Description:

5-Formyluracil is a chemical compound that belongs to the class of pyrimidine derivatives, specifically a substituted uracil. It features a formyl group (-CHO) at the 5-position of the uracil ring, which is a bicyclic structure composed of a six-membered and a five-membered ring containing nitrogen atoms. This compound is typically characterized by its white to off-white crystalline appearance and is soluble in polar solvents such as water and alcohols. 5-Formyluracil is of interest in biochemical research due to its potential role in nucleic acid metabolism and its implications in various biological processes. It can participate in reactions typical of aldehydes, such as condensation and oxidation, and may serve as an intermediate in the synthesis of other biologically relevant compounds. Additionally, its structural similarity to nucleobases makes it a subject of study in the context of molecular biology and medicinal chemistry, particularly in the development of therapeutic agents targeting nucleic acid interactions.

Formula: C₅H₄N₂O₃

InChI: InChI=1/C5H4N2O3/c8-2-3-1-6-5(10)7-4(3)9/h1-2H,(H2,6,7,9,10)

InChI key: InChIKey=OHAMXGZMZZWRCA-UHFFFAOYSA-N

SMILES: C(=O)C=1C(=O)NC(=O)NC1

Synonyms:

• 1,2,3,4-Tetrahydro-2,4-dioxo-5-pyrimidinecarboxaldehyde
• 2,4(1H,3H)-Pyrimidinedione, 5-formyl-
• 2,4-Dihydroxy-5-formylpyrimidine
• 2,4-Dihydroxy-pyrimidine-5-carbaldehyde
• 2,4-Dihydroxypyrimidine-5-carbaldehyde
• 2,4-Dioxo-1,2,3,4-Tetrahydropyrimidine-5-Carbaldehyde
• 2,4-Dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxaldehyde
• 2,4-Dioxo-1H-pyrimidine-5-carbaldehyde
• 5-
• 5-Pyrimidinecarboxaldehyde
• 5-Pyrimidinecarboxaldehyde, 1,2,3,4-tetrahydro-2,4-dioxo-
• Immureg
• NSC 197200
• NSC 241524
• Pyrimidinecarboxaldehyde
• Uracil-5-carboxaldehyde
• 5-Formyluracil
• 1,2,3,4-TETRAHYDRO-2,4-DIOXOPYRIMIDINE-5-CARBALDEHYDE
• RARECHEM AH CK 0106
• 5-FORMILURACIL
• 5-Formyluracil 98%
• AURORA KA-650

5-Formyluracil

CAS: 1195-08-0

Formula: C₅H₄N₂O₃

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 140.10

Ref: 3B-F1322

Uracil-5-carboxaldehyde, 97%

CAS: 1195-08-0

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Formula: C₅H₄N₂O₃

Purity: 97%

Molecular weight: 140.1

Ref: 02-H51098

5-Pyrimidinecarboxaldehyde, 1,2,3,4-tetrahydro-2,4-dioxo-

CAS: 1195-08-0

Formula: C₅H₄N₂O₃

Purity: 97%

Color and Shape: Solid

Molecular weight: 140.0969

Ref: IN-DA000IVX

Uracil-5-carboxaldehyde

CAS: 1195-08-0

Uracil-5-carboxaldehyde

Purity: 97%

Color and Shape: Solid

Molecular weight: 140.10g/mol

Ref: 54-OR4144

5-Formyl Uracil

Controlled Product

CAS: 1195-08-0

Applications Nucleoside derivatives of 5-substituted uracil have been explored for their potential application as anti-viral agents and in the treatment of tumors.
References Ressner, E.C., et al.: J. Med. Chem., 19, 1, 194 (1976)

Formula: C₅H₄N₂O₃

Color and Shape: Neat

Molecular weight: 140.10

Ref: TR-F701500

2,4-Dioxo-1,2,3,4-tetrahydropyrimidine-5-carbaldehyde

CAS: 1195-08-0

Formula: C₅H₄N₂O₃

Purity: 97%

Color and Shape: Solid

Molecular weight: 140.098

Ref: 10-F319128

5-Formyluracil

CAS: 1195-08-0

5-Formyluracil is a cytotoxic agent that has been shown to be effective against cancer tissues. It is genotoxic, and this activity is due to the pyrazole ring in its structure, which can react with DNA bases. 5-Formyluracil also inhibits the polymerase chain reaction (PCR) by preventing DNA synthesis. The mechanism of action of 5-formyluracil involves its ability to form covalent bonds with DNA bases and inhibit enzyme activities. This drug has been shown to have a mode of action similar to that of cisplatin and other platinum-containing compounds, but without the side effects associated with cisplatin therapy. The analytical method for determining 5-formyluracil levels in tissue is by gas chromatography/mass spectrometry (GC/MS).

Formula: C₅H₄N₂O₃

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 140.1 g/mol

Ref: 3D-FF07192