CAS 119567-63-4

Dimethylsphingosine

Description:

Dimethylsphingosine is a sphingolipid derivative characterized by its structural features, which include a long-chain fatty acid backbone and two methyl groups attached to the nitrogen atom of the sphingosine base. This compound is known for its role as a bioactive lipid mediator, influencing various cellular processes such as apoptosis, cell proliferation, and inflammation. It is often studied in the context of cell signaling and membrane dynamics. Dimethylsphingosine is soluble in organic solvents but has limited solubility in water, reflecting its hydrophobic nature typical of sphingolipids. The compound can act as a potent inhibitor of sphingosine-1-phosphate receptors, thereby modulating immune responses and vascular functions. Its biological activity and potential therapeutic implications make it a subject of interest in pharmacological research, particularly in the fields of cancer and cardiovascular diseases. As with many sphingolipids, the balance of its synthesis and degradation is crucial for maintaining cellular homeostasis and function.

Formula: C₂₀H₄₁NO₂

InChI: InChI=1/C20H41NO2/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-20(23)19(18-22)21(2)3/h16-17,19-20,22-23H,4-15,18H2,1-3H3/b17-16+/t19-,20+/m0/s1

InChI key: InChIKey=YRXOQXUDKDCXME-YIVRLKKSSA-N

SMILES: [C@H]([C@@H](/C=C/CCCCCCCCCCCCC)O)(N(C)C)CO

Synonyms:

• (2S,3R,4E)-2-(Dimethylamino)-4-octadecene-1,3-diol
• (2S,3R,4E)-2-(dimethylamino)octadec-4-ene-1,3-diol
• 2-Dimethylamino-4-Octadecene-1,3-Diol
• 2S-(Dimethylamino)-4E-Octadecene-1,3R-Diol
• 4-Octadecene-1,3-diol, 2-(dimethylamino)-, (2S,3R,4E)-
• 4-Octadecene-1,3-diol, 2-(dimethylamino)-, [R-[R*,S*-(E)]]-
• <span class="text-smallcaps">D</span>-erythro-N,N-Dimethylsphingosine
• D-Erythro-N,N-Dimethylsphingosine
• Dimethylsphingosine
• N,N-Dimethyl-<span class="text-smallcaps">D</span>-erythro-sphingosine
• N,N-Dimethyl-D-Erythro-Sphingosine
• N,N-Dimethylsphingosine
• N,N-Dimethylsphinogsine
• Sphingosine, N,N-Dimethyl
• D-ERYTHRO-SPHINGOSINE, N,N-DIMETHYL-
• DMS
• N,N-DIMETHYLSPHINGOSINE FROMD-SPHINGOSIN E
• N,N-DIMETHYLSPHINGOSINE, D-ERYTHRO
• N,N-dimethylsphingenine
• N,N-DIMETHYL-D-ERTHYRO-SPHINGOSINE

N,N-Dimethylsphingosine (d18:1)

CAS: 119567-63-4

Formula: C₂₀H₄₁NO₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 327.5450

Ref: IN-DA000IZ5

N,N-Dimethylsphingosine

CAS: 119567-63-4

Formula: C20H41NO2

Purity: >98%

Color and Shape: Solid

Molecular weight: 327.55

Ref: 48-56-1299

D-erythro-N,N-Dimethylsphingosine

Controlled Product

CAS: 119567-63-4

Applications D-erythro-N,N-Dimethylsphingosine is general modulator of protein kinases . D-erythro-N,N-Dimethylsphingosine is implicated in neuropathic pain.
References Igarashi, Y. et al.: Biochemistry, 28, 6796 (1989), Igarashi, Y. et al.: J. Biol. Chem., 265, 5385 (1990); Chemical and Engineering News, 90(4) 8 (2012)

Formula: C₂₀H₄₁NO₂

Color and Shape: Neat

Molecular weight: 327.54

Ref: TR-D479250

N,N-Dimethylsphingosine

CAS: 119567-63-4

N,N-Dimethylsphingosine,is a potent competitive SphK phosphorylation inhibitor.DMS is elevated in models of neuropathic pain by increasing IL-1β and MCP-1.

Formula: C₂₀H₄₁NO₂

Purity: 98%

Color and Shape: Clear Colorless To Faint Yellow Liquid/White To Off-White Powder

Molecular weight: 327.55

Ref: TM-T23045