CAS 1195767-77-1

Dabrafenib Hydroxy

Description:

Dabrafenib Hydroxy, identified by the CAS number 1195767-77-1, is a derivative of dabrafenib, which is a selective inhibitor of the BRAF kinase, primarily used in the treatment of certain types of melanoma and other cancers with BRAF mutations. This compound exhibits characteristics typical of small-molecule inhibitors, including the ability to interfere with specific signaling pathways involved in cell proliferation and survival. It is generally characterized by its moderate solubility in organic solvents and limited solubility in water, which can influence its bioavailability and pharmacokinetics. The hydroxy modification may enhance its pharmacological properties, potentially affecting its stability and interaction with biological targets. As with many pharmaceutical compounds, its efficacy and safety profile are determined through rigorous clinical testing, and it is essential to consider its mechanism of action, potential side effects, and interactions with other medications when evaluating its therapeutic use.

Formula: C₂₃H₂₀F₃N₅O₃S₂

Synonyms:

• Dabrafenib Hydroxy
• Benzenesulfonamide, N-[3-[5-(2-amino-4-pyrimidinyl)-2-(2-hydroxy-1,1-dimethylethyl)-4-thiazolyl]-2-fluorophenyl]-2,6-difluoro-
• Hydroxy Dabrafenib
• Dabrafenib Impurity 5
• Hydroxy Dabrafenib/N-[3-[5-(2-Amino-4-pyrimidinyl)-2-(2-hydroxy-1,1-dimethylethyl)-4-thiazolyl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide

Dabrafenib Impurity 2

CAS: 1195767-77-1

Formula: C₂₃H₂₀F₃N₅O₃S₂

Molecular weight: 535.56

Ref: 4Z-D-108005

Hydroxy Dabrafenib

CAS: 1195767-77-1

Applications Hydroxy Dabrafenib is a metabolite of Dabrafenib (D101000). Dabrafenib is an inhibitor of BRAF V600E used in the treatment metastatic melanoma.
References Vikingsson, Svante, et al.: Analy. and Bioanaly. Chem., 409(15), 3749-3756 (2017);Bershas, David A., et al.: Drug Metabol. & Dispos., 41(12), 2215-2224 (2013)

Formula: C₂₃H₂₀F₃N₅O₃S₂

Color and Shape: Neat

Molecular weight: 535.562

Ref: TR-H824995

Hydroxy dabrafenib

CAS: 1195767-77-1

Hydroxy dabrafenib is a drug product that has an analytical CAS number. It is a natural API impurity in the synthetic drug hydroxy dabrafenib. Hydroxy dabrafenib, also known as DAB-FEN-IB, is a synthetic drug with antioxidant and antiangiogenic properties. The compound inhibits the growth of cancerous cells by inhibiting the production of proteins vital for cell division. This drug product is used in research and development to assist in the discovery of new drugs.

Formula: C₂₃H₂₀F₃N₅O₃S₂

Purity: Min. 95%

Molecular weight: 535.60 g/mol

Ref: 3D-VXB76777

Hydroxy Dabrafenib

CAS: 1195767-77-1

Formula: C₂₃H₂₀F₃N₅O₃S₂

Molecular weight: 535.56

Ref: ST-EA-CP-D127008