CAS 119577-28-5

7-Ethyl-10-hydroxycamptothecin

Description:

7-Ethyl-10-hydroxycamptothecin, identified by its CAS number 119577-28-5, is a synthetic derivative of camptothecin, a compound originally derived from the bark of the Camptotheca acuminata tree. This substance exhibits potent antitumor activity, primarily through its mechanism of action as a topoisomerase I inhibitor, which interferes with DNA replication and transcription, leading to cell death in rapidly dividing cancer cells. It is characterized by its complex polycyclic structure, which includes a fused ring system and a hydroxyl group that enhances its solubility and biological activity. The compound is typically studied for its potential in cancer therapy, particularly in treating various solid tumors. Its pharmacokinetics, including absorption, distribution, metabolism, and excretion, are critical for determining its efficacy and safety profile. Additionally, ongoing research aims to optimize its formulation and delivery methods to improve therapeutic outcomes while minimizing side effects. Overall, 7-Ethyl-10-hydroxycamptothecin represents a significant focus in the development of novel anticancer agents.

Formula: C₂₂H₂₀N₂O₅

InChI: InChI=1/C20H16N2O5/c1-2-20(26)13-7-15-17-10(6-11-14(21-17)4-3-5-16(11)23)8-22(15)18(24)12(13)9-27-19(20)25/h3-7,23,26H,2,8-9H2,1H3/t20-/m0/s1

SMILES: CC[C@@]1(c2cc3c4c(cc5c(cccc5O)n4)Cn3c(=O)c2COC1=O)O

Synonyms:

• 1H-Pyrano3,4:6,7Indolizino1,2-Bquinoline-3,14(4H,12H)-Dione, 4-Ethyl-4,10-Dihydroxy-
• 7-Ethyl-10-Hydroxy Camptothecin
• 7-Ethyl-10-Hydroxy-Camptothecine
• 4,11-Diethyl-4,9-Dihydroxy-1H-Pyrano[3',4':6,7]Indolizino[1,2-B]Quinoline-3,14(4H,12H)-Dione
• (4S)-4,11-diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
• 4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
• Sn-38
• 7-Ethyl-10-hydroxycamptothecine
• Intermediate of Irinotecan 1

12-Ethyl-9-hydroxycamptothecin

CAS: 119577-28-5

12-Ethyl-9-hydroxycamptothecin

Purity: ≥98%

Molecular weight: 392.41g/mol

Ref: 54-BUP06660

12-Ethyl-9-hydroxycamptothecin

CAS: 119577-28-5

PAOPA is a dopamine D2 receptor modifier used in the study of schizophrenia and extrapyramidal dysfunction.

Formula: C₂₂H₂₀N₂O₅

Purity: 99.89%

Color and Shape: Solid

Molecular weight: 392.41

Ref: TM-TN2460