CAS 119623-66-4

Diclofenac epolamine

Description:

Diclofenac epolamine is a non-steroidal anti-inflammatory drug (NSAID) that is primarily used for its analgesic and anti-inflammatory properties. It is a derivative of diclofenac, which is known for its effectiveness in treating pain and inflammation associated with various conditions, such as arthritis and musculoskeletal disorders. The chemical structure of diclofenac epolamine includes an epolamine moiety, which enhances its transdermal absorption, making it suitable for topical formulations. This compound is typically formulated as a gel or patch for localized treatment, allowing for targeted delivery and reduced systemic side effects. Diclofenac epolamine exhibits a mechanism of action that involves the inhibition of cyclooxygenase enzymes, leading to decreased production of prostaglandins, which are mediators of pain and inflammation. Its pharmacokinetic profile allows for rapid onset of action, making it effective for acute pain relief. As with other NSAIDs, potential side effects may include gastrointestinal discomfort, cardiovascular risks, and allergic reactions, necessitating careful consideration of its use in patients with specific health conditions.

Formula: C₁₄H₁₁Cl₂NO₂·C₆H₁₃NO

InChI: InChI=1S/C14H11Cl2NO2.C6H13NO/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19;8-6-5-7-3-1-2-4-7/h1-7,17H,8H2,(H,18,19);8H,1-6H2

InChI key: InChIKey=DCERVXIINVUMKU-UHFFFAOYSA-N

SMILES: N(C1=C(CC(O)=O)C=CC=C1)C2=C(Cl)C=CC=C2Cl.C(CO)N1CCCC1

Synonyms:

• 1-Pyrrolidineethanol, 2-[(2,6-dichlorophenyl)amino]benzeneacetate (salt)
• Benzeneacetic acid, 2-[(2,6-dichlorophenyl)amino]-, compd. with 1-pyrrolidineethanol (1:1)
• Diclofenac 1-(2-hydroxyethyl)pyrrolidine salt
• Diclofenac Hydroxyethylpyrrolidine
• Diclofenac N-(2-hydroxyethyl)pyrrolidine salt
• Flector Patch
• {2-[(2,6-Dichlorophenyl)Amino]Phenyl}Acetic Acid - 2-(Pyrrolidin-1-Yl)Ethanol (1:1)
• Diclofenac epolamine

Benzeneacetic acid, 2-[(2,6-dichlorophenyl)amino]-, compd. with 1-pyrrolidineethanol (1:1)

CAS: 119623-66-4

Formula: C₂₀H₂₂Cl₂N₂O₂

Purity: 95%

Color and Shape: Solid

Molecular weight: 393.3069

Ref: IN-DA000PDN

Diclofenac Epolamine

CAS: 119623-66-4

Diclofenac Epolamine

Purity: ≥98%

Molecular weight: 411.32g/mol

Ref: 54-BUP10494

Diclofenac Epolamine

CAS: 119623-66-4

Diclofenac Epolamine (DHEP) is a non-steroidal anti-inflammatory agent (NSAID) with analgesic and antipyretic actions.

Formula: C₂₀H₂₄Cl₂N₂O₃

Purity: 99.56%

Color and Shape: Solid

Molecular weight: 411.32

Ref: TM-T22307

Diclofenac Epolamine

CAS: 119623-66-4

Stability Hygroscopic
Applications Diclofenac Epolamine is a diclofenac salt with greater water solubility and better cutaneous absorption properties than other commonly used forms of the drug. Diclofenac, a non-steroidal anti-inflammatory drugs (NSAIDs), is the mainstay of analgesic and anti-inflammatory treatment in dentistry.
References Serafini, G., et al.: Clin. Drug Invest., 32, 41 (2012); Fini, A., et al.: Eur. J. Pharm. Biopharm., 38, 66 (1992)

Formula: C₁₄H₁₁Cl₂NO₂·C₆H₁₃NO

Color and Shape: Neat

Molecular weight: 411.32

Ref: TR-D436470

2-(PYRROLIDIN-1-YL)ETHAN-1-OL 2-(2-((2,6-DICHLOROPHENYL)AMINO)PHENYL)ACETATE

CAS: 119623-66-4

Formula: C₂₀H₂₄Cl₂N₂O₃

Purity: 95.0%

Molecular weight: 411.32

Ref: 10-F533098

Diclofenac Epolamine

CAS: 119623-66-4

Diclofenac epolamine is a nonsteroidal anti-inflammatory drug that belongs to the class of diclofenac. It has been shown in clinical studies, with statistically significant results, to be effective against allergic reactions. Diclofenac epolamine is a film-forming polymer that can be used as a matrix for microcapsules containing diclofenac or other NSAIDs. This drug was designed to target tissue and provide effective analgesia at low doses. Diclofenac epolamine has an experimental model that uses monoclonal antibody-mediated delivery of diclofenac into the target tissue through microcapsules, which are then degraded by proteases present in the target tissue.

Formula: C₂₀H₂₂Cl₂N₂O₂

Purity: Min. 95%

Molecular weight: 393.31 g/mol

Ref: 3D-FD171589