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CAS 119637-66-0

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Metoprolol Fumarate

Description:
Metoprolol fumarate is a selective beta-1 adrenergic antagonist, primarily used in the treatment of hypertension, angina pectoris, and heart failure. It is a white to off-white crystalline powder that is soluble in water and exhibits good stability under normal conditions. The substance is a salt formed from metoprolol, a beta-blocker, and fumaric acid, which enhances its solubility and bioavailability. Metoprolol fumarate works by blocking the action of certain natural substances on the heart and blood vessels, leading to a decrease in heart rate and blood pressure. Its pharmacokinetics include rapid absorption, extensive hepatic metabolism, and a relatively short half-life, necessitating careful dosing to maintain therapeutic levels. The compound is typically administered orally and is available in various formulations, including extended-release tablets, which allow for once-daily dosing. As with any medication, potential side effects may include fatigue, dizziness, and bradycardia, and it should be used with caution in patients with certain pre-existing conditions.
Formula:C34H54N2O10
InChI:InChI=1/2C15H25NO3.C4H4O4/c2*1-12(2)16-10-14(17)11-19-15-6-4-13(5-7-15)8-9-18-3;5-3(6)1-2-4(7)8/h2*4-7,12,14,16-17H,8-11H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;;2-1-
SMILES:CC(C)NCC(COc1ccc(cc1)CCOC)O.CC(C)NCC(COc1ccc(cc1)CCOC)O.C(=C\C(=O)O)\C(=O)O
Synonyms:
  • Metoprolol fumarate [USAN]
  • (+-)-1-(Isopropylamino)-3-(p-(2-methoxyethyl)phenoxy)-2-propanol fumarate (2:1) (salt)
  • 2-Propanol, 1-(4-(2-methoxyethyl)phenoxy)-3-((1-methylethyl)amino)-, (+-)-, (E)-2-butanedioate (2:1) (salt)
  • Cgp 2175C
  • Lopresor OROS
  • Unii-Io1C09Z674
  • 1-[4-(2-methoxyethyl)phenoxy]-3-[(1-methylethyl)amino]propan-2-ol (2Z)-but-2-enedioate (2:1) (salt)
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