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CAS 119665-62-2

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Erythromycin, 6-O-methyl-2′,4′′-bis-O-(trimethylsilyl)-, 9-[O-(1-ethoxy-1-methylethyl)oxime]

Description:
Erythromycin, 6-O-methyl-2′,4′′-bis-O-(trimethylsilyl)-, 9-[O-(1-ethoxy-1-methylethyl)oxime] is a derivative of erythromycin, a macrolide antibiotic known for its effectiveness against a variety of bacterial infections. This specific compound features modifications that enhance its stability and solubility, which can improve its pharmacokinetic properties. The presence of trimethylsilyl groups suggests increased lipophilicity, potentially facilitating better membrane permeability. The oxime functional group may contribute to its reactivity and biological activity. As with many erythromycin derivatives, this compound likely exhibits antibacterial properties, targeting bacterial protein synthesis by binding to the 50S ribosomal subunit. Its structural modifications may also influence its spectrum of activity, resistance to degradation, and overall efficacy. However, detailed studies would be necessary to fully characterize its pharmacological profile, including its mechanism of action, therapeutic applications, and potential side effects. As with any chemical substance, safety and handling precautions should be observed, particularly in laboratory settings.
Formula:C49H96N2O14Si2
InChI:InChI=1S/C49H96N2O14Si2/c1-24-36-49(13,54)41(52)31(5)38(50-65-46(9,10)57-25-2)29(3)27-47(11,55-16)42(62-45-40(63-66(18,19)20)35(51(14)15)26-30(4)58-45)32(6)39(33(7)44(53)60-36)61-37-28-48(12,56-17)43(34(8)59-37)64-67(21,22)23/h29-37,39-43,45,52,54H,24-28H2,1-23H3/t29-,30-,31+,32+,33-,34+,35+,36-,37+,39+,40-,41-,42-,43+,45+,47-,48-,49-/m1/s1
InChI key:InChIKey=SFTHBPKNOPSKEE-PRWXDXEOSA-N
SMILES:O([C@H]1[C@@](OC)(C)C[C@@H](C)C(=NOC(OCC)(C)C)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@](OC)(C)[C@@H](O[Si](C)(C)C)[C@H](C)O2)[C@@H]1C)[C@H]3[C@H](O[Si](C)(C)C)[C@@H](N(C)C)C[C@@H](C)O3
Synonyms:
  • (3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-6-[(3S,4R,6S)-4-(dimethylamino)-6-methyl-3-trimethylsilyloxy-tetrahydropyran-2-yl]oxy-10-(1-ethoxy-1-methyl-ethoxy)imino-14-ethyl-12,13-dihydroxy-7-methoxy-4-[(4R,5S,6S)-4-methoxy-4,6-dimethyl-5-trimethylsilyloxy-tetrahydropyran-2-yl]oxy-3,5,7,9,11,13-hexamethyl-oxacyclotetradecan-2-one
  • Erythromycin, 6-O-methyl-2′,4′′-bis-O-(trimethylsilyl)-, 9-[O-(1-ethoxy-1-methylethyl)oxime]
  • Oxacyclotetradecane, erythromycin deriv.
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