CAS 119670-30-3

cbz-leu-val-gly diazomethyl ketone

Description:

Cbz-leu-val-gly diazomethyl ketone, identified by its CAS number 119670-30-3, is a synthetic compound that belongs to the class of peptide derivatives. It features a carbobenzoxy (Cbz) protecting group, which is commonly used in peptide synthesis to protect the amino group of the amino acid leucine (leu) in the sequence. The compound also includes valine (val) and glycine (gly) residues, contributing to its structural complexity. The presence of a diazomethyl ketone functional group indicates that it possesses reactive properties, making it useful in various chemical reactions, particularly in the field of medicinal chemistry and peptide research. This compound may exhibit biological activity due to its peptide-like structure, and its reactivity can facilitate further modifications or conjugations. As with many synthetic peptides, its stability, solubility, and reactivity can vary based on environmental conditions, such as pH and temperature, which are important considerations in its application and handling.

Formula: C₂₂H₃₁N₅O₅

InChI: InChI=1/C22H31N5O5/c1-14(2)10-18(26-22(31)32-13-16-8-6-5-7-9-16)20(29)27-21(30)19(15(3)4)24-11-17(28)12-25-23/h5-9,12,14-15,18-19,24H,10-11,13H2,1-4H3,(H2-,26,27,28,29,30,31)/b17-12-/t18-,19-/m0/s1

SMILES: CC(C)C[C@@H](C(=NC(=O)[C@H](C(C)C)NC/C(=C/[N+]#N)/O)O)N=C([O-])OCc1ccccc1

Synonyms:

• Z-Leu-Val-Gly-diazomethylketone
• (1Z)-3-{[(1S)-1-({N-[(benzyloxy)carbonyl]-L-leucyl}carbamoyl)-2-methylpropyl]amino}-1-diazonioprop-1-en-2-olate

Z-Leu-Val-Gly-diazomethylketone

CAS: 119670-30-3

The diazomethyl ketone Z-LVG-CHN2 mimics part of the human cysteine proteinase-binding center, has been shown to be an irreversible inhibitor of this proteinase. The compound was also tested for antiviral activity against herpes simplex virus type 1 (HSV) and found to block the HSV replication. Irreversible inhibitor of streptopain.

Formula: C₂₂H₃₁N₅O₅

Purity: > 98%

Color and Shape: Light Yellow Powder

Molecular weight: 445.52

Ref: 01-4016615

Z-Leu-Val-Gly-diazomethylketone

CAS: 119670-30-3

Z-Leu-Val-Gly-diazomethylketone is a prodrug that is metabolized in vivo to the active form, diazomethyl ketone. This drug has antiviral activity against a number of human pathogens, including poliovirus and herpes simplex virus. It also inhibits proteinase activity, which may be responsible for its anti-bacterial effects. Z-Leu-Val-Gly-diazomethylketone has been shown to inhibit pyogenes and staphylococci by cleavage of their cell walls. The drug also inhibits the replication of viruses such as human immunodeficiency virus (HIV) and influenza A virus.

Formula: C₂₂H₃₁N₅O₅

Purity: Min. 95%

Color and Shape: Off-White To Light (Or Pale) Yellow Solid

Molecular weight: 445.51 g/mol

Ref: 3D-FL111557