CAS 119687-33-1

Iganidipine

Description:

Iganidipine is a calcium channel blocker primarily used in the treatment of hypertension and angina pectoris. It belongs to the dihydropyridine class of calcium antagonists, which work by inhibiting the influx of calcium ions through L-type calcium channels in vascular smooth muscle and cardiac tissue. This action leads to vasodilation, reducing peripheral resistance and lowering blood pressure. Iganidipine is characterized by its ability to selectively target vascular tissues, minimizing effects on cardiac contractility. The compound exhibits a favorable pharmacokinetic profile, including good oral bioavailability and a relatively long half-life, allowing for once-daily dosing. Additionally, it has been noted for its potential to improve endothelial function and may possess antioxidant properties. As with other medications in its class, common side effects may include headache, dizziness, and peripheral edema. However, it is generally well-tolerated. As with any pharmaceutical, it is essential to consider contraindications and interactions with other medications when prescribing Iganidipine.

Formula: C₂₈H₃₈N₄O₆

InChI: InChI=1/C28H38N4O6/c1-7-11-30-12-14-31(15-13-30)17-28(4,5)18-38-27(34)24-20(3)29-19(2)23(26(33)37-6)25(24)21-9-8-10-22(16-21)32(35)36/h7-10,16,25,29H,1,11-15,17-18H2,2-6H3

SMILES: C=CCN1CCN(CC1)CC(C)(C)COC(=O)C1=C(C)NC(=C(C1c1cccc(c1)N(=O)=O)C(=O)OC)C

Synonyms:

• Iganidipine [INN]
• Unii-9Fpe98Dlz5
• (+-)-3-(4-Allyl-1-piperazinyl)-2,2-dimethylpropyl methyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate
• 2,2-Dimethyl-3-[4-(Prop-2-En-1-Yl)Piperazin-1-Yl]Propyl Methyl 2,6-Dimethyl-4-(3-Nitrophenyl)-1,4-Dihydropyridine-3,5-Dicarboxylate

Iganidipine

CAS: 119687-33-1

Iganidipine

Purity: ≥95%

Molecular weight: 526.62g/mol

Ref: 54-BUP21534

Iganidipine

Controlled Product

CAS: 119687-33-1

Formula: C₂₈H₃₈N₄O₆

Color and Shape: Neat

Molecular weight: 526.625

Ref: TR-I976550

Iganidipine

CAS: 119687-33-1

Iganidipine is a drug that is used to treat high blood pressure. It lowers the blood pressure by blocking calcium channels in the cell membrane of vascular smooth muscle cells, preventing them from contracting and relaxing. Iganidipine binds to functional groups on the receptor site and prevents calcium ions from entering the cell. This increases the amount of time it takes for an action potential in a nerve cell to travel to the next neuron, thereby lowering blood pressure. The drug has been shown to be effective in reducing glomerular filtration rate in rats. Iganidipine also has neuroprotective effects, which may be due to its ability to inhibit apoptosis and reduce oxidative stress.

Formula: C₂₈H₃₈N₄O₆

Purity: Min. 95%

Molecular weight: 526.6 g/mol

Ref: 3D-UEA68733

Iganidipine

CAS: 119687-33-1

Iganidipine（NKY 722） is a new water-soluble Ca2+ antagonist with antihypertensive activity for research and neurological related diseases.

Formula: C₂₈H₃₈N₄O₆

Purity: 96.3%

Color and Shape: Solid

Molecular weight: 526.62

Ref: TM-T15553