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CAS 119699-81-9

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Erythromycin, 6-O-Methyl-2',4'-Bis-O-(Trimethylsilyl)-, 9-[O-(1-Methoxy-1-Methylethyl)Oxime]

Description:
Erythromycin, 6-O-Methyl-2',4'-Bis-O-(Trimethylsilyl)-, 9-[O-(1-Methoxy-1-Methylethyl)Oxime] is a derivative of erythromycin, a macrolide antibiotic known for its effectiveness against a variety of bacterial infections. This specific compound features several modifications that enhance its pharmacological properties. The presence of trimethylsilyl groups increases its lipophilicity, potentially improving its absorption and bioavailability. The oxime functional group may contribute to its stability and reactivity, influencing its interaction with biological targets. Erythromycin derivatives are typically characterized by their ability to inhibit bacterial protein synthesis by binding to the 50S ribosomal subunit, thereby preventing the growth of susceptible bacteria. This compound may exhibit altered activity compared to the parent erythromycin, which can be advantageous in overcoming resistance mechanisms. Additionally, its structural modifications may affect its solubility, stability, and overall pharmacokinetic profile. As with many antibiotics, careful consideration of its therapeutic use, potential side effects, and resistance patterns is essential in clinical applications.
Formula:C49H96N2O14Si2
InChI:InChI=1/C49H96N2O14Si2/c1-24-36-49(13,54)41(52)31(5)38(50-65-46(9,10)57-25-2)29(3)27-47(11,55-16)42(62-45-40(63-66(18,19)20)35(51(14)15)26-30(4)58-45)32(6)39(33(7)44(53)60-36)61-37-28-48(12,56-17)43(34(8)59-37)64-67(21,22)23/h29-37,39-43,45,52,54H,24-28H2,1-23H3/b50-38+/t29-,30+,31+,32+,33-,34+,35-,36-,37?,39+,40+,41-,42-,43+,45?,47-,48-,49-/m1/s1
Synonyms:
  • (3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-6-[(3S,4R,6S)-4-(dimethylamino)-6-methyl-3-trimethylsilyloxy-tetrahydropyran-2-yl]oxy-10-(1-ethoxy-1-methyl-ethoxy)imino-14-ethyl-12,13-dihydroxy-7-methoxy-4-[(4R,5S,6S)-4-methoxy-4,6-dimethyl-5-trimethylsilyloxy-tetrahydropyran-2-yl]oxy-3,5,7,9,11,13-hexamethyl-oxacyclotetradecan-2-one
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