CAS 1197160-78-3

Gedatolisib

Description:

Gedatolisib is a small molecule inhibitor that targets the phosphoinositide 3-kinase (PI3K) and mammalian target of rapamycin (mTOR) pathways, which are crucial in regulating cell growth, proliferation, and survival. This dual inhibition makes Gedatolisib particularly relevant in cancer therapy, as many tumors exhibit dysregulation of these pathways. The compound is designed to enhance the efficacy of existing cancer treatments and is being investigated in clinical trials for various malignancies. Its chemical structure features specific functional groups that contribute to its activity and selectivity against the targeted kinases. Gedatolisib's pharmacokinetic properties, including absorption, distribution, metabolism, and excretion, are essential for determining its therapeutic potential and safety profile. As research continues, Gedatolisib may offer new avenues for treatment in oncology, particularly for patients with tumors that are resistant to conventional therapies. However, ongoing studies are necessary to fully understand its effectiveness and potential side effects in clinical settings.

Formula: C₃₂H₄₁N₉O₄

InChI: InChI=1S/C32H41N9O4/c1-38(2)27-11-13-39(14-12-27)29(42)24-5-9-26(10-6-24)34-32(43)33-25-7-3-23(4-8-25)28-35-30(40-15-19-44-20-16-40)37-31(36-28)41-17-21-45-22-18-41/h3-10,27H,11-22H2,1-2H3,(H2,33,34,43)

InChI key: InChIKey=DWZAEMINVBZMHQ-UHFFFAOYSA-N

SMILES: N(C(NC1=CC=C(C(=O)N2CCC(N(C)C)CC2)C=C1)=O)C3=CC=C(C=4N=C(N=C(N4)N5CCOCC5)N6CCOCC6)C=C3

Synonyms:

• 1-(4-(4-(Dimethylamino)piperidine-1-carbonyl)phenyl)-3-(4-(4,6-dimorpholino-1,3,5-triazin-2-yl)phenyl)urea
• 1-[4-[[4-(Dimethylamino)piperidin-1-yl]carbonyl]phenyl]-3-[4-[4,6-bis(morpholino)-1,3,5-triazin-2-yl]phenyl]urea
• Gedatolisib
• Pf 384
• Pf 5212384
• Pf-05212384
• Pk 1587
• Pki-587
• Urea, N-[4-[[4-(dimethylamino)-1-piperidinyl]carbonyl]phenyl]-N′-[4-(4,6-di-4-morpholinyl-1,3,5-triazin-2-yl)phenyl]-
• N-[4-[[4-(Dimethylamino)-1-piperidinyl]carbonyl]phenyl]-N′-[4-(4,6-di-4-morpholinyl-1,3,5-triazin-2-yl)phenyl]urea

Urea, N-[4-[[4-(dimethylamino)-1-piperidinyl]carbonyl]phenyl]-N'-[4-(4,6-di-4-morpholinyl-1,3,5-triazin-2-yl)phenyl]-

CAS: 1197160-78-3

Formula: C₃₂H₄₁N₉O₄

Purity: 99%

Color and Shape: Solid

Molecular weight: 615.7258

Ref: IN-DA000PHY

Gedatolisib

CAS: 1197160-78-3

Gedatolisib

Purity: ≥98%

Molecular weight: 615.73g/mol

Ref: 54-BUP05785

Gedatolisib

CAS: 1197160-78-3

Gedatolisib (PF-05212384) is a highly effective dual inhibitor targeting the PI3Kα/γ (IC50: 0.4/5.4 nM)and mTOR (IC50: 1.6 nM) in the PI3K/mTOR signaling

Formula: C₃₂H₄₁N₉O₄

Purity: 98% - 99.36%

Color and Shape: Solid

Molecular weight: 615.73

Ref: TM-T1970

PKI 587

CAS: 1197160-78-3

PI3K/mTOR kinase inhibitor; anti-neoplastic

Formula: C₃₂H₄₁N₉O₄

Purity: Min. 95%

Color and Shape: White To Off-White Solid

Molecular weight: 615.73 g/mol

Ref: 3D-FP65136