CAS 119733-44-7
:Sertraline Carbamoyl Glucuronide
Description:
Sertraline Carbamoyl Glucuronide is a metabolite of sertraline, an antidepressant belonging to the selective serotonin reuptake inhibitor (SSRI) class. This compound is formed through the glucuronidation process, which is a phase II metabolic reaction that enhances the solubility of drugs for excretion. Characteristically, Sertraline Carbamoyl Glucuronide is a polar, water-soluble compound, which facilitates its elimination from the body. It is typically found in biological fluids, such as urine, following the administration of sertraline. The presence of this metabolite can be indicative of sertraline use and is often studied in pharmacokinetic research to understand the drug's metabolism and excretion pathways. Its chemical structure includes a carbamoyl group and a glucuronic acid moiety, contributing to its pharmacological profile. Understanding the characteristics of this metabolite is essential for evaluating the therapeutic effects and potential side effects of sertraline in clinical settings.
Formula:C24H25Cl2NO8
InChI:InChI=1/C24H25Cl2NO8/c1-27(24(33)35-23-20(30)18(28)19(29)21(34-23)22(31)32)17-9-7-12(13-4-2-3-5-14(13)17)11-6-8-15(25)16(26)10-11/h2-6,8,10,12,17-21,23,28-30H,7,9H2,1H3,(H,31,32)/t12-,17-,18?,19?,20?,21?,23?/m0/s1
SMILES:CN([C@H]1CC[C@@H](c2ccc(c(c2)Cl)Cl)c2ccccc12)C(=O)OC1C(C(C(C(C(=O)O)O1)O)O)O
Synonyms:- (1S-cis)-1-[[4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenyl]methycarbamate]-b-D-glucopyranuronic Acid
- Sertraline Carbamoyl-O-glucuronid
- sertraline carbamoyl-O-glucuronide
- (1S-cis)-1-[[4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenyl]methycarbamate]--D-glucopyranuronic Acid
- 1-O-{[(1S,4S)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-yl](methyl)carbamoyl}hexopyranuronic acid
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Found 7 products.
β-D-Glucopyranuronic acid, 1-[[4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenyl]methylcarbamate], (1S-cis)- (9CI)
CAS:Formula:C24H25Cl2NO8Color and Shape:SolidMolecular weight:526.3632Sertraline carbamoyl-β-D-glucuronide
CAS:Sertraline carbamoyl-β-D-glucuronideMolecular weight:526.3632g/molSertraline Carbamoyl Glucuronide
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications The major metabolite of the antidepressant Sertraline.<br>References Myers, C.E., et al.: Pharmacol. Rev., 33, 1 (1981), Bosslet, K., et al.: Cancer Res., 58, 1195 (1998), Tremaine et. al.: Drug Metabolism and Disposition 17, 542 (1989)<br></p>Formula:C24H25Cl2NO8Color and Shape:NeatMolecular weight:526.36Sertraline carbamoyl glucuronide
CAS:<p>Sertraline is a selective serotonin reuptake inhibitor (SSRI) that is used primarily in the treatment of depression and anxiety. It inhibits the serotonin transporter protein, making more serotonin available for binding to postsynaptic receptors. Sertraline also has a minor inhibitory effect on norepinephrine and dopamine reuptake, but its primary function is as a selective serotonin reuptake inhibitor. The major metabolite of sertraline is sertraline carbamoyl glucuronide, which is formed through glucuronidation by UGT2B7. This metabolite has been found to be bifurcated with one half being excreted in urine and the other half being excreted in faeces. The half that undergoes urinary excretion has been shown to have a half-life of 24 hours whereas the other half has a much shorter half-life of 2 hours. Carbamoylation of sertraline may</p>Formula:C24H25Cl2NO8Purity:Min. 95%Molecular weight:526.36 g/mol
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