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CAS 119770-54-6

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11-deazahomofolic acid

Description:
11-Deazahomofolic acid is a synthetic derivative of folic acid, characterized by the absence of a nitrogen atom in the 11-position of the pteridine ring. This modification alters its biochemical properties and interactions. The compound is primarily studied for its role as a potential inhibitor of dihydrofolate reductase, an enzyme critical in the folate metabolism pathway, which is essential for DNA synthesis and repair. As a result, 11-deazahomofolic acid has garnered interest in cancer research and the development of antifolate drugs. Its structural modifications may enhance its efficacy and selectivity compared to traditional folate analogs. The compound is typically soluble in polar solvents, and its stability can be influenced by pH and temperature. Additionally, it may exhibit varying degrees of biological activity depending on the specific cellular context and the presence of other metabolic factors. Overall, 11-deazahomofolic acid represents a significant area of study in medicinal chemistry, particularly in the context of targeted therapies.
Formula:C21H22N6O6
InChI:InChI=1/C21H22N6O6/c22-21-26-17-16(19(31)27-21)24-13(10-23-17)3-1-2-11-4-6-12(7-5-11)18(30)25-14(20(32)33)8-9-15(28)29/h4-7,10,14H,1-3,8-9H2,(H,25,30)(H,28,29)(H,32,33)(H3,22,23,26,27,31)/t14-/m0/s1
Synonyms:
  • N-(4-(3-(2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)propyl)benzoyl)-L-glutamic acid
  • L-Glutamic acid, N-(4-(3-(2-amino-1,4-dihydro-4-oxo-6-pteridinyl)propyl)benzoyl)-
  • N-{4-[3-(2-amino-4-oxo-1,4-dihydropteridin-6-yl)propyl]benzoyl}-L-glutamic acid
  • 11-Deazahomofolic acid
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