CAS 119794-51-3
:2'-TBDMS-Ac-rC
Description:
2'-TBDMS-Ac-rC, also known as 2'-O-(tert-butyldimethylsilyl)acetyl-5-methylcytidine, is a modified nucleoside that features a tert-butyldimethylsilyl (TBDMS) protecting group at the 2' hydroxyl position and an acetyl group at the 5' position of the ribose sugar. This compound is primarily used in nucleic acid chemistry, particularly in the synthesis of RNA oligonucleotides, where it serves to enhance stability and solubility. The TBDMS group provides protection against hydrolysis, while the acetyl group can facilitate further chemical modifications. The presence of the methyl group on the cytosine base contributes to its unique properties, influencing base pairing and hybridization characteristics. Overall, 2'-TBDMS-Ac-rC is valuable in research applications involving RNA synthesis, allowing for the creation of modified oligonucleotides with improved performance in various biochemical assays and therapeutic contexts. Its structural modifications make it a useful tool in the development of RNA-based technologies.
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