CAS 1198-47-6

6-Methylthioguanine

Description:

6-Methylthioguanine is a purine derivative and a methylated analog of guanine, characterized by the presence of a methylthio group at the 6-position of the guanine structure. Its molecular formula is C6H8N4OS, and it has a molecular weight that reflects its composition of carbon, hydrogen, nitrogen, oxygen, and sulfur atoms. This compound is primarily studied for its role in nucleic acid metabolism and its potential implications in cancer research, as it can influence DNA synthesis and repair mechanisms. 6-Methylthioguanine can act as a substrate for various enzymes involved in nucleotide metabolism, and its incorporation into DNA can lead to mutagenic effects. The compound is soluble in polar solvents, which facilitates its interaction with biological systems. Additionally, it is important to handle this substance with care due to its potential biological activity and effects on cellular processes. Overall, 6-Methylthioguanine serves as a significant compound in the study of molecular biology and pharmacology.

Formula: C₆H₇N₅S

InChI: InChI=1S/C6H7N5S/c1-12-5-3-4(9-2-8-3)10-6(7)11-5/h2H,1H3,(H3,7,8,9,10,11)

InChI key: InChIKey=YEGKYFQLKYGHAR-UHFFFAOYSA-N

SMILES: S(C)C1=C2C(=NC(N)=N1)N=CN2

Synonyms:

• 2-Amino-6-methylthiopurine
• Purine, 2-amino-6-(methylthio)-
• 9H-Purin-2-amine, 6-(methylthio)-
• 1H-Purin-2-amine, 6-(methylthio)-
• 6-(Methylthio)-9H-purin-2-amine

9H-Purin-2-amine, 6-(methylthio)-

CAS: 1198-47-6

Formula: C₆H₇N₅S

Purity: 98%

Color and Shape: Solid

Molecular weight: 181.2183

Ref: IN-DA000PNT

6-(Methylsulfanyl)-7h-purin-2-amine

CAS: 1198-47-6

6-(Methylsulfanyl)-7h-purin-2-amine

Purity: 98%

Molecular weight: 181.22g/mol

Ref: 54-OR82807

2-Amino-6-methylmercaptopurine

CAS: 1198-47-6

Formula: C₆H₇N₅S

Molecular weight: 181.22

Ref: 7W-GK7394

6-Methylthioguanine

CAS: 1198-47-6

Formula: C₆H₇N₅S

Color and Shape: Neat

Molecular weight: 181.22

Ref: 04-C15144205

6-Methylthioguanine

CAS: 1198-47-6

Applications A metabolite of 2’-Deoxy-6-thio Guanosine (D281650) and 6-Thioguanine. An effective immunosuppressant and anticancer agent, however chronic exposure can be mutagenic in human cells as long-term use of thiopurines was found to be associated with a significantly increased risk of various types of cancer.
References Loo, T.L. et al.: Cancer Chemother. Pharmacol., 6, 131 (1981); Yuan, B. et al.: ACS Chem. Biol., 5, 1021 (2010); Kroplin, T. et al.: Adv. Exp. Med. Biol., 431, 741 (1998);

Formula: C₆H₇N₅S

Color and Shape: Neat

Molecular weight: 181.22

Ref: TR-M330720

6-(Methylsulfanyl)-7h-purin-2-amine

CAS: 1198-47-6

Purity: 98%

Molecular weight: 181.2200012

Ref: 10-F672975

2-Amino-6-methylmercaptopurine

CAS: 1198-47-6

2-Amino-6-methylmercaptopurine is a thioguanine drug that inhibits complex enzymes in the purine metabolism pathway. It has been shown to have inhibitory properties against cell-specific enzymes and to be capable of reducing nucleotide levels in cells. 2-Amino-6-methylmercaptopurine also has anti-inflammatory effects, which may be due to its ability to induce autophagy in intestinal epithelial cells. The anticancer effects of 2AMMMP are related to its ability to inhibit DNA synthesis and protein synthesis. This drug has been used as an adjunct therapy for bowel disease, but it is not active against carcinoma cell lines or fetal bovines.

Formula: C₆H₇N₅S

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 181.22 g/mol

Ref: 3D-FA07966

6-Methylthioguanine

CAS: 1198-47-6

Formula: C₆H₇N₅S

Molecular weight: 181.22

Ref: ST-EA-CP-A88051