CAS 119898-59-8
:5'-O-(4,4'-Dimethoxytrityl)-inosine
Description:
5'-O-(4,4'-Dimethoxytrityl)-inosine is a modified nucleoside that features a purine base, inosine, which is linked to a ribose sugar. The modification involves the attachment of a 4,4'-dimethoxytrityl (DMT) protecting group at the 5' position of the sugar, enhancing its stability and solubility, and facilitating its use in various biochemical applications, particularly in oligonucleotide synthesis. This compound is characterized by its ability to protect the 5' hydroxyl group during synthetic processes, allowing for selective reactions at other functional sites. The presence of methoxy groups in the DMT moiety contributes to its hydrophobic nature, influencing its interaction with solvents and other reagents. Additionally, 5'-O-(4,4'-Dimethoxytrityl)-inosine is often utilized in the synthesis of RNA and DNA analogs, making it valuable in research areas such as molecular biology, genetic engineering, and therapeutic development. Its CAS number, 119898-59-8, is a unique identifier that facilitates the cataloging and retrieval of information regarding this specific chemical substance in scientific literature and databases.
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Found 5 products.
5'-O-DMT-rI
CAS:5’-O-DMT-Ri can be used in the synthesis of oligoribonucleotides[1].Formula:C31H30N4O7Color and Shape:SolidMolecular weight:570.595'-O-DMT-inosine
CAS:<p>5'-O-DMT-inosine is a novel monophosphate nucleotide analogue. It is modified by the attachment of an aminooxy group to the 5' position of the pentose. This modification prevents ribonucleotide reductase from converting it into deoxyribonucleotides, which are then incorporated into DNA. 5'-O-DMT-inosine has been shown to be cytotoxic in human leukemia cells due to its ability to inhibit the synthesis of DNA and RNA.</p>Formula:C31H30N4O7Purity:Min. 95%Molecular weight:570.59 g/mol
