CAS 119914-60-2

Grepafloxacin

Description:

Grepafloxacin is a synthetic fluoroquinolone antibiotic that exhibits broad-spectrum antibacterial activity. It is primarily effective against a variety of Gram-positive and Gram-negative bacteria, making it useful in treating respiratory and urinary tract infections. The compound functions by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes critical for DNA replication and transcription. Grepafloxacin is characterized by its relatively high oral bioavailability and a favorable pharmacokinetic profile, allowing for effective systemic distribution. However, like other fluoroquinolones, it may be associated with side effects, including gastrointestinal disturbances, central nervous system effects, and potential tendon damage. Its use has been limited in some regions due to concerns over safety and the emergence of bacterial resistance. Grepafloxacin's chemical structure includes a bicyclic core with a fluorine atom, which enhances its antibacterial potency compared to earlier generations of quinolones. Overall, while it has therapeutic applications, careful consideration of its risks and benefits is essential in clinical practice.

Formula: C₁₉H₂₂FN₃O₃

InChI: InChI=1S/C19H22FN3O3/c1-10-8-22(6-5-21-10)15-7-14-16(11(2)17(15)20)18(24)13(19(25)26)9-23(14)12-3-4-12/h7,9-10,12,21H,3-6,8H2,1-2H3,(H,25,26)

InChI key: InChIKey=AIJTTZAVMXIJGM-UHFFFAOYSA-N

SMILES: O=C1C=2C(N(C=C1C(O)=O)C3CC3)=CC(=C(F)C2C)N4CC(C)NCC4

Synonyms:

• Grepafloxacin
• 1-Cyclopropyl-6-fluoro-1,4-dihydro-5-methyl-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid
• 3-Quinolinecarboxylic acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-5-methyl-7-(3-methyl-1-piperazinyl)-4-oxo-
• Tomefloxacin
• 1-Cyclopropyl-6-fluoro-7-(3-methyl-1-piperazinyl)-5-methyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acid

3-Quinolinecarboxylic acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-5-methyl-7-(3-methyl-1-piperazinyl)-4-oxo-

CAS: 119914-60-2

Formula: C₁₉H₂₂FN₃O₃

Purity: 95%

Color and Shape: Solid

Molecular weight: 359.3947

Ref: IN-DA001EET

Grepafloxacin

CAS: 119914-60-2

Grepafloxacin, an oral fluoroquinolone antibiotic, effectively treats respiratory infections, especially Streptococcus pneumoniae.

Formula: C₁₉H₂₂FN₃O₃

Color and Shape: Solid

Molecular weight: 359.39

Ref: TM-T38586

Grepafloxacin

CAS: 119914-60-2

Formula: C₁₉H₂₂FN₃O₃

Molecular weight: 359.40

Ref: 4Z-G-223001

dl-Grepafloxacin Hydrochloride

Controlled Product

CAS: 119914-60-2

Applications dl-Grepafloxacin Hydrochloride is an antibacterial compound used to treat various respirator infections.
References O'Shea, R. et al.: J. Med. Chem., 51, 2871 (2008); Zhanel, G. et al.: Drugs, 62, 13 (2002);

Formula: C₁₉H₂₂FN₃O₃•x(HCl)

Color and Shape: White To Beige

Molecular weight: 359.393646

Ref: TR-G783005

Grepafloxacin hydrochloride

CAS: 119914-60-2

Broad-spectrum fluoroquinolone antibacterial agent

Formula: C₁₉H₂₂FN₃O₃•(HCl)x

Purity: Min. 95%

Molecular weight: 395.86 g/mol

Ref: 3D-FG104075

Grepafloxacin

CAS: 119914-60-2

Grepafloxacin is a synthetic fluoroquinolone antibiotic, which is derived from the chemical modification of natural quinolones. It acts by inhibiting bacterial DNA gyrase and topoisomerase IV. This inhibition disrupts DNA replication and transcription in bacteria, leading to cell death. The high affinity of grepafloxacin for these bacterial enzymes over human analogs makes it an effective antibacterial agent, specifically targeting the bacterial replication machinery.

Formula: C₁₉H₂₂FN₃O₃

Purity: Min. 95%

Molecular weight: 359.39 g/mol

Ref: 3D-FG71825