CAS 1199350-02-1

Itraconazole Desethylene-seco-piperazine Di-N-formyl Impurity

Description:

Itraconazole Desethylene-seco-piperazine Di-N-formyl Impurity, identified by its CAS number 1199350-02-1, is a chemical compound related to the antifungal agent itraconazole. This impurity is characterized by its structural modifications, which include the desethylene and seco-piperazine moieties, along with two formyl groups. Such modifications can influence the compound's solubility, stability, and biological activity compared to the parent itraconazole molecule. Typically, impurities like this can arise during the synthesis or degradation of pharmaceuticals and may affect the overall efficacy and safety profile of the drug. The presence of impurities is a critical consideration in pharmaceutical development, as they can impact the pharmacokinetics and pharmacodynamics of the active ingredient. Analytical techniques such as HPLC, NMR, and mass spectrometry are often employed to identify and quantify such impurities in drug formulations. Understanding the characteristics of this impurity is essential for ensuring the quality and safety of itraconazole-containing products.

Formula: C₃₅H₃₆Cl₂N₈O₆

Synonyms:

• Formamide, N-[2-[[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]formylamino]ethyl]-N-[4-[1,5-dihydro-1-(1-methylpropyl)-5-oxo-4H-1,2,4-triazol-4-yl]phenyl]-, rel-
• ItracozoleDesethylene-seco-piperazineDi-N-formylImpurity
• Itraconazole Desethylene-seco-piperazine Di-N-formyl Impurity

Itraconazole Impurity 37

CAS: 1199350-02-1

Formula: C₃₅H₃₆Cl₂N₈O₆

Molecular weight: 735.62

Ref: 4Z-I-0364

Itraconazole Desethylene-seco-piperazine Di-N-formyl Impurity

Controlled Product

CAS: 1199350-02-1

Applications Itraconazole Desethylene-seco-piperazine Di-N-formyl Impurity is a by-product in the synthesis of Itraconazole Desethylene-seco-piperazine Mono-N-formyl Impurity (I937520), which is an impurity of Itraconazole (I937500). Itraconazole is an orally active antimycotic structurally related to Ketoconazole. Antifungal. It is a COVID19-related research product.
References Espinel-Ingroff, A., et al.: Antimicrob. Agents Chemother., 26, 5 (1984), Heykants, J., et al.: Mycoses, 32, Suppl 1, 67 (1989), Sugar, A.M.,et al.: Curr. Clin. Top. Infect. Dis., 13, 74 (1993),

Formula: C₃₅H₃₆Cl₂N₈O₆

Color and Shape: Neat

Molecular weight: 735.62

Ref: TR-I937565

Itraconazole Impurity 32

CAS: 1199350-02-1

Formula: C₃₅H₃₆Cl₂N₈O₆

Molecular weight: 735.6

Ref: ST-EA-CP-I3069