CAS 1199945-26-0
:N-Benzyl (-)-Nebivolol
Description:
N-Benzyl (-)-Nebivolol is a selective beta-1 adrenergic receptor blocker, primarily used in the treatment of hypertension and heart failure. This compound is characterized by its chiral nature, with the (-)-enantiomer being the active form that exhibits higher affinity for beta-1 receptors compared to its counterpart. It is known for its vasodilatory properties, which are attributed to its ability to stimulate the release of nitric oxide, leading to relaxation of vascular smooth muscle. The molecular structure includes a benzyl group, contributing to its lipophilicity, which enhances its bioavailability. Additionally, N-Benzyl (-)-Nebivolol has a favorable pharmacokinetic profile, including a relatively long half-life, allowing for once-daily dosing. Its side effect profile is generally mild, making it a preferred choice in managing cardiovascular conditions. As with other beta-blockers, caution is advised in patients with asthma or certain heart conditions, as it may exacerbate bronchospasm or bradycardia. Overall, N-Benzyl (-)-Nebivolol represents a significant advancement in cardiovascular pharmacotherapy.
Formula:C29H31F2NO4
Synonyms:- 2H-1-Benzopyran-2-methanol, α,α'-[[(phenylmethyl)imino]bis(methylene)]bis[6-fluoro-3,4-dihydro-, (αS,α'S,2R,2'S)-
- N-Benzyl (-)-Nebivolol
- Benzylated Nebivolol
- (αS,α'S,2R,2'S)-α,α'-[[(PhenylMethyl)iMino]bis(Methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-Methanol
- Nebivolol N-Benzyl Impurity
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Found 3 products.
N-Benzyl (-)-Nebivolol
CAS:<p>Applications (-)-Nebivolol (N387895(M)) intermediate. (-)-Nebivolol is a β1-Adrenergic blocker and used as an antihypertensive.<br>References Van de Water, A., et al.: J. Cardiovasc. Pharmacol., 11, 552 (1988), De Cree, J., et al.: Angiology, 41, 95 (1990)<br></p>Formula:C29H31F2NO4Color and Shape:NeatMolecular weight:495.56
