CAS 120-97-8

Dichlorphenamide

Description:

Dichlorphenamide, with the CAS number 120-97-8, is a chemical compound that belongs to the class of sulfonamide drugs. It is primarily recognized for its diuretic properties and is used in the treatment of conditions such as glaucoma and edema. The compound features a dichlorophenyl group, which contributes to its pharmacological activity. Dichlorphenamide is typically a white to off-white crystalline powder that is soluble in water and exhibits moderate stability under standard conditions. Its mechanism of action involves the inhibition of carbonic anhydrase, an enzyme that plays a crucial role in the regulation of bicarbonate and fluid balance in the body. This inhibition leads to increased excretion of bicarbonate, sodium, and water, thereby promoting diuresis. As with many sulfonamides, it may have potential side effects, including allergic reactions and electrolyte imbalances. Proper medical supervision is essential when using this compound to mitigate risks and monitor therapeutic efficacy.

Formula: C₆H₆Cl₂N₂O₄S₂

InChI: InChI=1S/C6H6Cl2N2O4S2/c7-4-1-3(15(9,11)12)2-5(6(4)8)16(10,13)14/h1-2H,(H2,9,11,12)(H2,10,13,14)

InChI key: InChIKey=GJQPMPFPNINLKP-UHFFFAOYSA-N

SMILES: S(N)(=O)(=O)C1=CC(S(N)(=O)=O)=CC(Cl)=C1Cl

Synonyms:

• 1, 2-Dichlorobenzene-3, 5-disulfoneamide
• 1,3-Benzenedisulfonamide, 4,5-dichloro-
• 1,3-Disulfamoyl-4,5-dichlorobenzene
• 1,3-Disulfamyl-4,5-dichlorobenzene
• 3,4-Dichloro-5-sulfamylbenzenesulfonamide
• 4,5-Dichloro-1,3-benzenedisulfonamide
• 4,5-Dichloro-1,3-disulfamoylbenzene
• 4,5-Dichloro-m-benzenedisulfonamide
• 4,5-Dichlorobenzene-1,3-Disulfonamide
• 4,5-Dichlorobenzene-1,3-Disulphonamide
• Antidrasi
• Cb 8000
• Daramide
• Daranide
• Dichlofenamide
• Dichlorophenamide
• Diclofenamid
• Diclofenamida
• Diclofenamide
• Glaucol
• Keveyis
• Oratrol

Dichlorphenamide

CAS: 120-97-8

Formula: C₆H₆Cl₂N₂O₄S₂

Purity: >95.0%(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 305.14

Ref: 3B-D5996

Dichlorphenamide

CAS: 120-97-8

Color and Shape: White To Off-White

Ref: 61-FOR1795.00

Dichlorphenamide

CAS: 120-97-8

Sulfonamides used as drugs

Formula: C₆H₆Cl₂N₂O₄S₂

Color and Shape: White Powder

Molecular weight: 303.9146

Ref: 45-1188006

1,3-Benzenedisulfonamide, 4,5-dichloro-

CAS: 120-97-8

Formula: C₆H₆Cl₂N₂O₄S₂

Purity: 97%

Color and Shape: Solid

Molecular weight: 305.1588

Ref: IN-DA000Q1A

Dichlorphenamide (Diclofenamide)

CAS: 120-97-8

Formula: C₆H₆Cl₂N₂O₄S₂

Color and Shape: White To Off-White Solid

Molecular weight: 305.16

Ref: 4Z-D-149001

Dichlorphenamide

CAS: 120-97-8

Dichlorphenamide

Purity: ≥95%

Molecular weight: 305.16g/mol

Ref: 54-BUP15548

Dichlorphenamide

CAS: 120-97-8

Formula: C₆H₆N₂Cl₂O₄S₂

Molecular weight: 305.16

Ref: 7W-GP0999

Dichlorphenamide

CAS: 120-97-8

Dichlorphenamide

Purity: 97%

Molecular weight: 305.16g/mol

Ref: 54-OR1025313

Dichlorphenamide

CAS: 120-97-8

Formula: C₆H₆Cl₂N₂O₄S₂

Color and Shape: Neat

Molecular weight: 305.16

Ref: 86-MM1795.00

Dichlorphenamide

CAS: 120-97-8

Dichlorphenamide (Diclofenamide) is a carbonic anhydrase inhibitor that is used in the treatment of glaucoma.

Formula: C₆H₆Cl₂N₂O₄S₂

Purity: 96.87% - 97.25%

Color and Shape: Needles From Dimethylsulfoxide + Water Solid

Molecular weight: 305.16

Ref: TM-T6469

Diclofenamide

Controlled Product

CAS: 120-97-8

Applications Diclofenamide is a potent carbonic anhydrase inhibitor. Diclofenamide may provide a therapeutic strategy in the inhibition of the human cytosolic isoforms I and II and transmembrane tumor-associated isoenzymes IX and XII. Diclofenamide has been shown to be is effective in the prevention of episodic weakness in both hypokalemic periodic paralysis (HypoPP) and potassium-sensitive periodic paralysis (PSPP).
References Brzozowski, Z. et al.: Eur. J. Med. Chem., 46, 3656 (2010); Tawil, R. et al.: Ann. Neurol., 47, 46 (2000); Casey, J. et al.: J. Med. Chem., 47, 2337 (2004);

Formula: C₆H₆Cl₂N₂O₄S₂

Color and Shape: Neat

Molecular weight: 305.16

Ref: TR-D436530

DICHLORPHENAMIDE

CAS: 120-97-8

Purity: 99%

Molecular weight: 305.1400146

Ref: 10-F798404