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CAS 120013-57-2

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5-O-Desmethyl donepezil

Description:
5-O-Desmethyl donepezil, identified by its CAS number 120013-57-2, is a chemical compound related to donepezil, a medication commonly used to treat Alzheimer's disease. This substance is characterized by its structural modifications, specifically the absence of a methyl group at the 5-position of the donepezil molecule. As a result, it may exhibit different pharmacological properties compared to its parent compound. Typically, such modifications can influence the compound's potency, selectivity, and metabolic stability. 5-O-Desmethyl donepezil may interact with acetylcholinesterase, an enzyme involved in the breakdown of acetylcholine, thereby potentially enhancing cholinergic neurotransmission. The compound's solubility, stability, and bioavailability are also important characteristics that can affect its therapeutic efficacy. Research into its specific biological activities and potential applications continues, as understanding these properties can lead to the development of more effective treatments for cognitive disorders.
Formula:C23H27NO3
InChI:InChI=1S/C23H27NO3/c1-27-22-14-20-18(13-21(22)25)12-19(23(20)26)11-16-7-9-24(10-8-16)15-17-5-3-2-4-6-17/h2-6,13-14,16,19,25H,7-12,15H2,1H3
InChI key:InChIKey=DSMISVLYMKJMLP-UHFFFAOYSA-N
SMILES:O=C1C=2C(CC1CC3CCN(CC4=CC=CC=C4)CC3)=CC(O)=C(OC)C2
Synonyms:
  • 1-Benzyl-4-[(5-hydroxy-6-methoxy-1-oxo-indan-2-yl)methyl]piperidine
  • 1-Benzyl-4-[(5-hydroxy-6-methoxy-1-oxo-indan-2-yl)methylpiperidine
  • 1H-Inden-1-one, 2,3-dihydro-5-hydroxy-6-methoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-
  • 2,3-Dihydro-5-hydroxy-6-methoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-one
  • 2-[(1-Benzylpiperidin-4-yl)methyl]-5-hydroxy-6-methoxy-2,3-dihydroinden-1-one
  • 2-[(1-benzylpiperidin-4-yl)methyl]-5-hydroxy-6-methoxy-2,3-dihydro-1H-inden-1-one
  • 5-O-Desmethyl donepezil
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