CAS 120013-84-5
:RAC (CIS/TRANS) DONEPEZIL N-OXIDE
Description:
RAC (CIS/TRANS) Donepezil N-Oxide, with the CAS number 120013-84-5, is a chemical compound related to donepezil, a well-known acetylcholinesterase inhibitor used primarily in the treatment of Alzheimer's disease. This compound is characterized by its structural modifications that include the presence of an N-oxide functional group, which can influence its pharmacological properties and bioavailability. The "RAC" designation indicates that the substance is a racemic mixture, containing both enantiomers, which may exhibit different biological activities. The cis/trans notation refers to the geometric isomerism in the compound, affecting its spatial arrangement and potentially its interaction with biological targets. As a derivative of donepezil, this compound may retain similar mechanisms of action, but its specific efficacy, safety profile, and pharmacokinetics would require thorough investigation through experimental studies. Overall, RAC (CIS/TRANS) Donepezil N-Oxide represents a modification of a therapeutic agent with potential implications in neuropharmacology.
Formula:C24H29NO4
InChI:InChI=1/C24H29NO4/c1-28-22-14-19-13-20(24(26)21(19)15-23(22)29-2)12-17-8-10-25(27,11-9-17)16-18-6-4-3-5-7-18/h3-7,14-15,17,20H,8-13,16H2,1-2H3
SMILES:COc1cc2CC(CC3CCN(=O)(CC3)Cc3ccccc3)C(=O)c2cc1OC
Synonyms:- 2,3-Dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-n-oxide-cis/trans-1H-inden-1-one
- 2,3-Dihydro-5,6-dimethoxy-2-[[cis/trans-1-oxido-1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-one
- 2-[(1-benzyl-1-oxidopiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one
- RAC (CIS/TRANS) DONEPEZIL N-OXIDE
- 2,3-Dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-one N-oxide
- Donepezil-N-Oxide (20 mg)
- (cis/trans)-2,3-Dihydro-5,6-diMethoxy-2-[[1-(phenylMethyl)-4-
- Donepezil Impurity G
- Donepezil-N-Oxide
- piperidinyl]Methyl]-1H-Inden-1-one
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Found 10 products.
Donepezil-N-Oxide
CAS:Compounds containing an unfused pyridine ring in the structure, nesoiFormula:C24H29NO4Color and Shape:PowderMolecular weight:395.209661H-Inden-1-one, 2,3-dihydro-5,6-dimethoxy-2-[[1-oxido-1-(phenylmethyl)-4-piperidinyl]methyl]-
CAS:Formula:C24H29NO4Purity:99%Color and Shape:SolidMolecular weight:395.49141-Benzyl-4-((5,6-dimethoxy-1-oxo-2,3-dihydro-1H-inden-2-yl)methyl)piperidine 1-oxide
CAS:1-Benzyl-4-((5,6-dimethoxy-1-oxo-2,3-dihydro-1H-inden-2-yl)methyl)piperidine 1-oxidePurity:99%Molecular weight:395.5g/molDonepezil N-oxide
CAS:Donepezil N-oxide, a donepezil metabolite, inhibits human ChE with 45.5% at 20 μM.Formula:C24H29NO4Color and Shape:SolidMolecular weight:395.49rac-(cis/trans) Donepezil N-Oxide
CAS:Controlled ProductFormula:C24H29NO4Color and Shape:White To Light BrownMolecular weight:395.49rac-(cis/trans) Donepezil N-oxide
CAS:<p>Donepezil is a drug that belongs to the class of cholinesterase inhibitors. It is used in the treatment of Alzheimer's disease, dementia and other central nervous system disorders. Donepezil has been shown to inhibit the enzyme acetylcholinesterase (AChE) by binding to its active site. This binding prevents the breakdown of acetylcholine, which leads to an accumulation of this neurotransmitter in the synaptic cleft and an increase in cholinergic activity at nerve junctions. The inhibitor formic acid is formed as a result of the rearrangement of racemic donepezil N-oxide. Donepezil N-oxide can be metabolized by peroxidases or reduced by glutathione reductase, leading to the formation of formic acid, which may contribute to its toxicity.</p>Formula:C24H29NO4Purity:Min. 95%Color and Shape:Beige PowderMolecular weight:395.49 g/mol
![1H-Inden-1-one, 2,3-dihydro-5,6-dimethoxy-2-[[1-oxido-1-(phenylmethyl)-4-piperidinyl]methyl]-](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FIN%2Fthumb%2FDA000Q2L.jpg&w=3840&q=75)
