CAS 1200493-78-2

Atabecestat

Description:

Atabecestat, with the CAS number 1200493-78-2, is a small molecule that functions as a selective inhibitor of the enzyme BACE1 (beta-site amyloid precursor protein cleaving enzyme 1). This enzyme plays a crucial role in the production of amyloid-beta peptides, which are implicated in the pathogenesis of Alzheimer's disease. Atabecestat has been investigated for its potential to reduce amyloid-beta levels in the brain, thereby aiming to slow the progression of Alzheimer's. The compound is characterized by its specific binding affinity to BACE1, which allows it to effectively inhibit the enzyme's activity. In terms of its chemical structure, Atabecestat features a complex arrangement of functional groups that contribute to its pharmacological properties. It is typically administered orally and has undergone various clinical trials to assess its efficacy and safety profile. However, like many investigational drugs, it may have associated side effects and contraindications that need to be considered in therapeutic contexts.

Formula: C₁₈H₁₄FN₅OS

Synonyms:

• 2-Pyridinecarboxamide, N-[3-[(4S)-2-amino-4-methyl-4H-1,3-thiazin-4-yl]-4-fluorophenyl]-5-cyano-
• JNJ-54861911
• Atabecestat (JNJ-54861911)
• Atabecestat

Atabecestat

CAS: 1200493-78-2

Atabecestat

Purity: ≥98%

Molecular weight: 367.4g/mol

Ref: 54-BUP09039

Atabecestat

CAS: 1200493-78-2

Atabecestat is a drug that belongs to the group of metabotropic glutamate receptor (mGluR) antagonists. It is a small molecule that blocks the mGluR5 receptor and prevents glutamate from binding, thereby reducing inflammation in inflammatory bowel disease. Atabecestat has been shown to be effective in patients with Crohn's disease and ulcerative colitis, as well as those with more severe forms of IBD. The drug has also been shown to be safe for long-term use in clinical trials, including one study that lasted up to 1 year and another study that was conducted for 2 years.

Formula: C₁₈H₁₅ClFN₅OS

Purity: Min. 95%

Molecular weight: 403.9 g/mol

Ref: 3D-AYB49378

Atabecestat

CAS: 1200493-78-2

Atabecestat (JNJ-54861911) is an oral BACE1 inhibitor for Alzheimer's treatment with strong brain uptake and lasting PK/PD effects.

Formula: C₁₈H₁₄FN₅OS

Purity: 99.21% - 99.77%

Color and Shape: Solid

Molecular weight: 367.4

Ref: TM-T14338