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CAS 120066-54-8

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Gadoteridol

Description:
Gadoteridol is a paramagnetic contrast agent primarily used in magnetic resonance imaging (MRI) to enhance the visibility of internal structures. It is a gadolinium-based compound, which means it contains gadolinium, a rare earth metal known for its strong magnetic properties. Gadoteridol is characterized by its high relaxivity, which improves the contrast between different tissues in MRI scans. It is typically administered intravenously and is particularly effective in imaging the central nervous system, including the brain and spinal cord. The substance is water-soluble and has a low osmolality, which contributes to its safety profile. Gadoteridol is generally well-tolerated, but like other gadolinium-based agents, it carries a risk of nephrogenic systemic fibrosis (NSF) in patients with severe renal impairment. Its chemical structure includes a cyclohexane ring and a hydroxypyridine moiety, which contribute to its stability and efficacy as a contrast agent. Overall, Gadoteridol is a vital tool in diagnostic imaging, aiding in the detection and characterization of various medical conditions.
Formula:C17H29GdN4O7
InChI:InChI=1S/C17H32N4O7.Gd/c1-14(22)10-18-2-4-19(11-15(23)24)6-8-21(13-17(27)28)9-7-20(5-3-18)12-16(25)26;/h14,22H,2-13H2,1H3,(H,23,24)(H,25,26)(H,27,28);/q;+3/p-3
InChI key:InChIKey=DPNNNPAKRZOSMO-UHFFFAOYSA-K
SMILES:CC1[OH][Gd+3]234567[N]8(CC(=O)[O-]2)CC[N]3(C1)CC[N]4(CC(=O)[O-]5)CC[N]6(CC(=O)[O-]7)CC8
Synonyms:
  • Gadolinium, [10-(2-hydroxypropyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triacetato(3-)-N1,N4,N7,N10,O1,O4,O7,O10]-
  • 1,4,7,10-Tetraazacyclododecane, gadolinium deriv.
  • gadolinium 2,2',2''-[10-(2-hydroxypropyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl]triacetate
  • [10-[2-(Hydroxy-κO)propyl]-1,4,7,10-tetraazacyclododecane-1,4,7-triacetato(3-)-κN1,κN4,κN7,κN10,κO1,κO4,κO7]gadolinium
  • Gadolinium, [10-[2-(hydroxy-κO)propyl]-1,4,7,10-tetraazacyclododecane-1,4,7-triacetato(3-)-κN1,κN4,κN7,κN10,κO1,κO4,κO7]-
  • 1,4,7,10-Tetraazacyclododecane-1,4,7-triacetic acid, 10-(2-hydroxypropyl)-, gadolinium complex
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