CAS 120081-14-3

Goralatide

Description:

Goralatide, with the CAS number 120081-14-3, is a synthetic peptide that has been studied primarily for its potential therapeutic applications. It is classified as a cyclic peptide and is known for its role in modulating biological processes, particularly in the context of cancer treatment and immunotherapy. The structure of Goralatide includes specific amino acid sequences that contribute to its biological activity, allowing it to interact with various receptors in the body. Its mechanism of action often involves the inhibition of tumor growth and the enhancement of immune responses. Goralatide has undergone various preclinical and clinical studies to evaluate its efficacy and safety profile. As with many peptides, its stability, solubility, and bioavailability are critical factors that influence its therapeutic potential. Overall, Goralatide represents a promising candidate in the field of peptide-based therapeutics, although further research is necessary to fully understand its capabilities and optimize its use in clinical settings.

Formula: C₂₀H₃₃N₅O₉

InChI: InChI=1/C20H33N5O9/c1-11(27)22-14(10-26)18(31)24-13(9-16(28)29)17(30)23-12(5-2-3-7-21)19(32)25-8-4-6-15(25)20(33)34/h12-15,26H,2-10,21H2,1H3,(H,22,27)(H,23,30)(H,24,31)(H,28,29)(H,33,34)/t12-,13-,14-,15-/m0/s1

SMILES: CC(=N[C@@H](CO)C(=N[C@@H](CC(=O)O)C(=N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)O)O)O)O

Synonyms:

• 1-(N2-(N-(N-Acetyl-L-seryl)-L-a-aspartyl)-L-lysyl)-L-proline
• 120081-14-3
• N-Acetyl-L-seryl-L-alpha-aspartyl-L-lysyl-L-proline

Ac-Ser-Asp-Lys-Pro-OH

CAS: 120081-14-3

The bioactive tetrapeptide goralatide which corresponds to the N-terminus of Thymosin β₄, is a physiological regulator of hematopoiesis and inhibits the entry into the S-phase of murine and human hematopoietic stem cells. Ac-SDKP has been shown to reduce the damage to specific compartments in the bone marrow resulting from treatment with chemotherapeutic agents, ionizing radiations, hyperthermy, or phototherapy. It protects from doxorubicin-induced toxicity. Ac-SDKP is a physiological substrate of angiotensin I- converting enzyme (ACE).

Formula: C₂₀H₃₃N₅O₉

Purity: 98.7%

Color and Shape: White

Molecular weight: 487.51

Ref: 01-4016348

Malantide acetate(86555-35-3 free base)

CAS: 120081-14-3

Malantide acetate(86555-35-3 free base)

Purity: ≥98%

Molecular weight: 1693.97g/mol

Ref: 54-BUP20376

Goralatide

CAS: 120081-14-3

Goralatide, isolated from fetal calf bone marrow, exerts a high inhibitory activity on the proliferation of hematopoietic pluripotent stem cells.

Formula: C₂₀H₃₃N₅O₉

Purity: 98%

Color and Shape: Solid

Molecular weight: 487.5

Ref: TM-TP2339