CAS 120138-50-3: Quinupristin

Description: Quinupristin is a semi-synthetic antibiotic that belongs to the streptogramin class of antibiotics, primarily used in combination with dalfopristin to treat serious infections caused by Gram-positive bacteria, including vancomycin-resistant Enterococcus faecium. It functions by inhibiting bacterial protein synthesis, specifically targeting the 50S ribosomal subunit. Quinupristin exhibits a broad spectrum of activity against various pathogens, making it effective in treating conditions such as skin and soft tissue infections, as well as complicated intra-abdominal infections. The compound is known for its unique mechanism of action, which involves binding to distinct sites on the ribosome, leading to synergistic effects when used in combination with dalfopristin. Quinupristin is typically administered intravenously and may cause side effects such as gastrointestinal disturbances and potential hepatotoxicity. Its use is often reserved for cases where other antibiotics are ineffective due to resistance, highlighting its importance in the fight against antibiotic-resistant bacteria.

Formula: C₅₃H₆₇N₉O₁₀S

InChI: InChI=1/C53H67N9O10S/c1-6-37-50(68)61-23-11-14-38(61)51(69)59(5)40(26-32-16-18-36(19-17-32)58(3)4)52(70)62-28-35(30-73-43-29-60-24-20-33(43)21-25-60)42(64)27-39(62)47(65)57-45(34-12-8-7-9-13-34)53(71)72-31(2)44(48(66)55-37)56-49(67)46-41(63)15-10-22-54-46/h7-10,12-13,15-19,22,31,33,35,37-40,43-45,63H,6,11,14,20-21,23-30H2,1-5H3,(H,55,66)(H,56,67)(H,57,65)/t31-,35+,37?,38+,39?,40+,43-,44+,45+/m1/s1

Synonyms:

• Quinupristin [USAN:INN]
• N-((6R,9S,10R,13S,15aS,18R,22S,24aS)-22-(p-(Dimethylamino)benzyl)-6-ethyldocosahydro-10,23-dimethyl-5,8,12,15,17,21,24-heptaoxo-13-phenyl-18-(((3S)-3-quinuclidinylthio)methyl)-12H-pyrido(2,1-f)pyrrolo(2,1-l)(1,4,7,10,13,16)oxapentaazacyclononadecin-9-yl)-3-hydroxypicolinamide
• Quinupristina
• Quinupristina [INN-Spanish]
• Quinupristine
• Quinupristine [INN-French]
• Quinupristinum
• Quinupristinum [INN-Latin]
• Unii-23Ow28Rs7P
• Virginiamycin S1, 4-(4-(dimethylamino)-N-methyl-L-phenylalanine)-5-(5-((1-azabicyclo(2.2.2)oct-3-ylthio)methyl)-4-oxo-L-2-piperidinecarboxylic acid)-, (S)-
• N-{18-[(1-azabicyclo[2.2.2]oct-3-ylsulfanyl)methyl]-22-[4-(dimethylamino)benzyl]-6-ethyl-10,23-dimethyl-5,8,12,15,17,21,24-heptaoxo-13-phenyldocosahydro-12H-pyrido[2,1-f]pyrrolo[2,1-l][1,4,7,10,13,16]oxapentaazacyclononadecin-9-yl}-3-hydroxypyridine-2-carboxamide

Quinupristin

CAS: 120138-50-3

• Formula: C₅₄H₇₁N₉O₁₃S₂
• Purity: 97%
• Color and Shape: Solid
• Molecular weight: 1118.3240400000013

Quinupristin

CAS: 120138-50-3

• Molecular weight: 1022.2

Quinupristin

CAS: 120138-50-3

Quinupristin, a macrolide-lincosamide-streptogramin antibiotic, inhibits protein synthesis in bacteria.

• Formula: C₅₃H₆₇N₉O₁₀S
• Purity: 98.16%
• Color and Shape: Solid
• Molecular weight: 1022.22

Quinupristin

CAS: 120138-50-3

Quinupristin is an antibacterial agent that exhibits potent activity against Escherichia coli. It has been …

• Formula: C₅₃H₆₇N₉O₁₀S
• Purity: Min. 95%
• Molecular weight: 1,022.22 g/mol