CAS 1201438-56-3

IPI 145

Description:

IPI-145, also known as duvelisib, is a small molecule inhibitor that targets phosphoinositide 3-kinase (PI3K) pathways, specifically the delta and gamma isoforms. It is primarily investigated for its potential therapeutic applications in hematological malignancies, including certain types of lymphoma and leukemia. IPI-145 exhibits anti-tumor activity by disrupting the signaling pathways that promote cell proliferation and survival in cancer cells. The compound is typically administered orally and has been evaluated in clinical trials for its efficacy and safety profile. Its mechanism of action involves the inhibition of PI3K, which plays a crucial role in various cellular processes, including metabolism, growth, and survival. As with many targeted therapies, the side effects may include immune-related reactions, gastrointestinal disturbances, and hematological changes. Ongoing research continues to explore its full potential and optimize its use in combination with other therapies for enhanced treatment outcomes in oncology.

Formula: C₂₂H₁₇ClN₆O

InChI: InChI=1S/C22H17ClN6O/c1-13(28-21-19-20(25-11-24-19)26-12-27-21)17-10-14-6-5-9-16(23)18(14)22(30)29(17)15-7-3-2-4-8-15/h2-13H,1H3,(H2,24,25,26,27,28)/t13-/m0/s1

InChI key: InChIKey=SJVQHLPISAIATJ-ZDUSSCGKSA-N

SMILES: [C@H](NC1=C2C(N=CN2)=NC=N1)(C)C=3N(C(=O)C=4C(C3)=CC=CC4Cl)C5=CC=CC=C5

Synonyms:

• 1(2H)-Isoquinolinone, 8-chloro-2-phenyl-3-[(1S)-1-(9H-purin-6-ylamino)ethyl]-
• 8-Chloro-2-phenyl-3-[(1S)-1-(9H-purin-6-ylamino)ethyl]-1(2H)-isoquinolinone
• Copiktra
• Ink 1197
• Ink1197
• Ipi 145
• Duvelisib

1(2H)-Isoquinolinone, 8-chloro-2-phenyl-3-[(1S)-1-(9H-purin-6-ylamino)ethyl]-

CAS: 1201438-56-3

Formula: C₂₂H₁₇ClN₆O

Purity: 98%

Color and Shape: Solid

Molecular weight: 416.8630

Ref: IN-DA000QE2

Duvelisib

CAS: 1201438-56-3

Duvelisib

Purity: ≥98%

Molecular weight: 416.86g/mol

Ref: 54-BUP14419

Duvelisib-d5

CAS: 1201438-56-3

Formula: C₂₂H₁₂D₅ClN₆O

Molecular weight: 421.90

Ref: 4Z-D-247002

Duvelisib

CAS: 1201438-56-3

Formula: C₂₂H₁₇ClN₆O

Molecular weight: 416.87

Ref: 4Z-D-247001

Duvelisib

CAS: 1201438-56-3

Duvelisib (INK1197, IPI-145) is a selective inhibitor of phosphatidylinositol 3-kinase (PI3K) and p100δ.Cost-effective and quality-assured.

Formula: C₂₂H₁₇ClN₆O

Purity: 98.87% - 99.74%

Color and Shape: Solid

Molecular weight: 416.86

Ref: TM-T1988

IPI-145

CAS: 1201438-56-3

Ref: 7W-GW3149

IPI 145

Controlled Product

CAS: 1201438-56-3

Applications IPI 145 is an 1,2-dihydroisoquinolin-1(2H)-one derivative and has been developed as a modulator of PI3 kinase.

Formula: C₂₂H₁₇ClN₆O

Color and Shape: Neat

Molecular weight: 416.86

Ref: TR-I739400

IPI 145

CAS: 1201438-56-3

Inhibitor of PI3KΎ and PI3Kγ kinases

Formula: C₂₂H₁₇ClN₆O

Purity: Min. 95%

Molecular weight: 416.86 g/mol

Ref: 3D-FP43074