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IPI 145

CAS 1201438-56-3: IPI 145

Description:IPI-145, also known as duvelisib, is a small molecule inhibitor that targets phosphoinositide 3-kinase (PI3K) pathways, specifically the delta and gamma isoforms. It is primarily investigated for its potential therapeutic applications in hematological malignancies, including certain types of lymphoma and leukemia. IPI-145 exhibits anti-tumor activity by disrupting the signaling pathways that promote cell proliferation and survival in cancer cells. The compound is typically administered orally and has been evaluated in clinical trials for its efficacy and safety profile. Its mechanism of action involves the inhibition of PI3K, which plays a crucial role in various cellular processes, including metabolism, growth, and survival. As with many targeted therapies, the side effects may include immune-related reactions, gastrointestinal disturbances, and hematological changes. Ongoing research continues to explore its full potential and optimize its use in combination with other therapies for enhanced treatment outcomes in oncology.

Formula:C22H17ClN6O

InChI:InChI=1S/C22H17ClN6O/c1-13(28-21-19-20(25-11-24-19)26-12-27-21)17-10-14-6-5-9-16(23)18(14)22(30)29(17)15-7-3-2-4-8-15/h2-13H,1H3,(H2,24,25,26,27,28)/t13-/m0/s1

InChI key:InChIKey=SJVQHLPISAIATJ-ZDUSSCGKSA-N

SMILES:O=C1C=2C(Cl)=CC=CC2C=C(N1C=3C=CC=CC3)C(NC4=NC=NC=5N=CNC54)C

  • Synonyms:
  • 1(2H)-Isoquinolinone, 8-chloro-2-phenyl-3-[(1S)-1-(9H-purin-6-ylamino)ethyl]-
  • 8-Chloro-2-phenyl-3-[(1S)-1-(9H-purin-6-ylamino)ethyl]-1(2H)-isoquinolinone
  • Copiktra
  • Ink 1197
  • Ink1197
  • Ipi 145
  • Duvelisib
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1(2H)-Isoquinolinone, 8-chloro-2-phenyl-3-[(1S)-1-(9H-purin-6-ylamino)ethyl]-

CAS:1201438-56-3

Ref: IN-DA000QE2

1gTo inquire
1mg61.00 €
5mg114.00 €
10mg161.00 €
25mg208.00 €
50mg333.00 €
100mg660.00 €
Estimated delivery in United States, on Tuesday 4 Mar 2025
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Ref: 4Z-D-247001

5mgTo inquire
10mgTo inquire
25mgTo inquire
50mgTo inquire
100mgTo inquire
Estimated delivery in United States, on Wednesday 5 Mar 2025
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Ref: 4Z-D-247002

5mgTo inquire
10mgTo inquire
25mgTo inquire
50mgTo inquire
100mgTo inquire
Estimated delivery in United States, on Wednesday 5 Mar 2025
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Duvelisib

CAS:1201438-56-3

Ref: TM-T1988

2mg48.00 €
5mg66.00 €
10mg93.00 €
50mg156.00 €
100mg244.00 €
Estimated delivery in United States, on Tuesday 11 Mar 2025
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IPI-145

CAS:1201438-56-3

Ref: 7W-GW3149

1mg293.00 €
5mg443.00 €
10mg719.00 €
Estimated delivery in United States, on Tuesday 11 Mar 2025
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IPI 145

Controlled Product
CAS:1201438-56-3

Ref: TR-I739400

5mg126.00 €
10mg186.00 €
100mg723.00 €
Estimated delivery in United States, on Friday 14 Mar 2025
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IPI 145

CAS:1201438-56-3

Ref: 3D-FP43074

10mg348.00 €
50mg408.00 €
Estimated delivery in United States, on Tuesday 15 Apr 2025
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Duvelisib, Free Base

CAS:1201438-56-3

Discontinued product
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