CAS 1201898-17-0

Vinflunine Tartrate

Description:

Vinflunine tartrate is a synthetic vinca alkaloid derivative primarily used in cancer treatment, particularly for advanced or metastatic transitional cell carcinoma of the bladder. It functions as a microtubule inhibitor, disrupting the normal function of the mitotic spindle during cell division, which ultimately leads to cell cycle arrest and apoptosis in rapidly dividing cancer cells. The compound is characterized by its complex molecular structure, which includes a core structure derived from the periwinkle plant, Vinca rosea. Vinflunine tartrate is typically administered intravenously and has a specific pharmacokinetic profile, including metabolism primarily via the liver and excretion through the kidneys. Its efficacy is often evaluated in clinical settings, and it may be associated with side effects common to chemotherapeutic agents, such as neutropenia, fatigue, and gastrointestinal disturbances. As with any chemotherapeutic agent, careful monitoring and management of adverse effects are essential during treatment.

Formula: C₄₅H₅₄F₂N₄O₈·xC₄H₆O₆

Synonyms:

• Vinflunine Tartrate USP/EP/BP
• Aspidospermidine-3-carboxylic acid, 4-(acetyloxy)-6,7-didehydro-15-[(2R,4R,6S,8S)-4-(1,1-difluoroethyl)-1,3,4,5,6,7,8,9-octahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-, methyl ester, (2β,3β,4β,5α,12R,19β)-, (2R,3R)-2,3-dihydroxybutanedioate (1:x)
• Vinflunine Tartrate (F12158)
• Aspidospermidine-3-carboxylic acid, 4-(acetyloxy)-6,7-didehydro-15-[(2R,4R,6S,8S)-4-(1,1-difluoroethyl)-1,3,4,5,6,7,8,9-octahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-, methyl ester

Vinflunine Tartrate

CAS: 1201898-17-0

Vinflunine Tartrate, a uniquely fluorinated vinca alkaloid, exhibits mitotic-arresting and tubulin-interacting properties.

Formula: C₄₅H₅₄F₂N₄O₈·xC₄H₆O₆

Purity: 98%

Color and Shape: Solid

Molecular weight: 967.02

Ref: TM-T6722

Vinflunine tartrate

CAS: 1201898-17-0

Vinflunine tartrate is a chemotherapeutic agent, which is a semi-synthetic vinca alkaloid derivative sourced primarily from the plant Catharanthus roseus. This compound stands out due to its synthetic modifications that incorporate fluorine atoms, enhancing its pharmacokinetic properties compared to its parent compounds. The mode of action of vinflunine tartrate involves the inhibition of microtubule assembly by binding to tubulin, effectively disrupting the mitotic spindle formation in dividing cells. This results in the arrest of the cell cycle at the metaphase, ultimately leading to apoptotic cell death.

Formula: C₄₅H₅₄F₂N₄O₈·xC₄H₆O₆

Purity: Min. 95%

Ref: 3D-FV35264