CAS 120202-71-3

(R)-Clopidogrel bisulfate

Description:

(R)-Clopidogrel bisulfate is an antiplatelet medication primarily used to prevent blood clots in patients with cardiovascular diseases. It is a prodrug that requires metabolic activation to exert its therapeutic effects, specifically inhibiting the P2Y12 receptor on platelets, thereby preventing platelet aggregation. The compound is characterized by its chiral nature, with the (R)-enantiomer being the active form responsible for its pharmacological activity. Clopidogrel bisulfate is typically administered orally and is well-absorbed in the gastrointestinal tract, although its bioavailability is affected by first-pass metabolism. The substance is often formulated as a bisulfate salt to enhance its solubility and stability. Common side effects include bleeding complications, gastrointestinal disturbances, and, in rare cases, hypersensitivity reactions. Due to its mechanism of action, it is crucial for patients to be monitored for signs of bleeding, especially when used in conjunction with other anticoagulants or antiplatelet agents. Overall, (R)-Clopidogrel bisulfate plays a significant role in the management of thrombotic disorders.

Formula: C₁₆H₁₆ClNO₂S·H₂O₄S

InChI: InChI=1S/C16H16ClNO2S.H2O4S/c1-20-16(19)15(12-4-2-3-5-13(12)17)18-8-6-14-11(10-18)7-9-21-14;1-5(2,3)4/h2-5,7,9,15H,6,8,10H2,1H3;(H2,1,2,3,4)/t15-;/m1./s1

InChI key: InChIKey=FDEODCTUSIWGLK-XFULWGLBSA-N

SMILES: [C@@H](C(OC)=O)(N1CC2=C(CC1)SC=C2)C3=C(Cl)C=CC=C3.S(=O)(=O)(O)O

Synonyms:

• (R)-(-)-Methyl (2-chlorophenyl)(6,7-dihydro-4H-thieno[3,2-c]pyrid-5-yl)acetate bisulfate
• (R)-(-)-Methyl 2-(2-chlorophenyl)-2-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)acetate hydrogen sulfate
• (R)-Clopidogrel bisulfate
• (R)-Methyl 2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetate sulfate
• Clopidogrel Related Compound C
• Methyl(-)-(R)-(o-chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-acetate, hydrogen sulfate
• Sr 25989C
• Thieno[3,2-c]pyridine-5(4H)-acetic acid, α-(2-chlorophenyl)-6,7-dihydro-, methyl ester, (αR)-, sulfate (1:1)
• methyl (2R)-(2-chlorophenyl)(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)ethanoate sulfate

Clopidogrel Related Compound C (methyl (-)-(R)-(o-chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-acetate, hydrogen sulfate)

CAS: 120202-71-3

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

Formula: C₁₆H₁₆ClNO₂S·H₂SO₄

Color and Shape: White Powder

Molecular weight: 321.05903

Ref: 45-1140600

(R)-Methyl 2-(2-chlorophenyl)-2-(4,5-dihydrothieno[2,3-c]pyridin-6(7h)-yl)acetate sulfate

CAS: 120202-71-3

Formula: C₁₆H₁₈ClNO₆S₂

Purity: 97%

Color and Shape: Solid

Molecular weight: 419.9002

Ref: IN-DA0081B8

Clopidogrel EP Impurity C Sulfate (Clopidogrel USP Related Compound C, (R)-Clopidogrel Sulfate)

CAS: 120202-71-3

Formula: C₁₆H₁₆ClNO₂S·H₂SO₄

Color and Shape: White To Off-White Solid

Molecular weight: 321.82 98.07

Ref: 4Z-C-1314

Clopidogrel Related Compound C

CAS: 120202-71-3

Clopidogrel Related Compound C

Purity: ≥95%

Molecular weight: 419.89g/mol

Ref: 54-BUP18818

Methyl (2R)-(2-Chlorophenyl)[6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl]acetate Hydrogen Sulfate ((R)-Clopidogrel Hydrogen Sulfate)

CAS: 120202-71-3

Color and Shape: Neat

Ref: 86-MM0455.12

Clopidogrel Related Compound C

CAS: 120202-71-3

(R)-Clopidogrel bisulfate (Clopidogrel Related Compound C) is an isomer of clopidogrel. Clopidogrel is a P2Y12 receptor antagonist.

Formula: C₁₆H₁₈ClNO₆S₂

Purity: 97.84%

Color and Shape: Solid

Molecular weight: 419.9

Ref: TM-T126236

R-(-)-Clopidogrel Hydrogen Sulfate

Controlled Product

CAS: 120202-71-3

Impurity Clopidogrel EP Impurity C
Stability Very Hygroscopic
Applications R-(-)-Clopidogrel Hydrogen Sulfate (Clopidogrel EP Impurity C) is used as an antithrombotic. Clopidogrel Related Compound C
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Mills, D.C.B., et al.: Arterioscler. Thromb., 12, 430 (1992), Feuerstein, G., et al.: Exp. Opin. Invest. Drugs, 4, 425 (1995)

Formula: C₁₆H₁₆ClNO₂S·H₂O₄S

Color and Shape: White

Molecular weight: 419.90

Ref: TR-C587251

Clopidogrel EP Impurity C

CAS: 120202-71-3

Formula: C₁₆H₁₆ClNO₂SH₂O₄S

Molecular weight: 321.8 : 98.1

Ref: ST-EA-CP-C2003

R-(-)-Clopidogrel hydrogen sulfate

CAS: 120202-71-3

R-(-)-Clopidogrel hydrogen sulfate is a prodrug of clopidogrel, which is an antiplatelet agent. It is used to prevent thrombotic events in people with coronary artery disease, peripheral arterial disease, or cerebrovascular disease. The drug is broken down in the liver and then converted to an active form by the enzyme CYP2C19. The R-(-)-isomer of clopidogrel has been shown to be more effective for reducing platelet aggregation than its S-enantiomer, with no difference in effectiveness between the two forms for reducing heart attacks and strokes. This drug can be found in wastewater samples due to its use as a therapeutic agent. The method used for analysis was LC-MS/MS and the excipients were not reported.

Formula: C₁₆H₁₈ClNO₆S₂

Purity: Min. 98 Area-%

Color and Shape: White Slightly Yellow Powder

Molecular weight: 419.02641

Ref: 3D-FC20512