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CAS 120279-36-9

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Dorzolomide hydrochloride

Description:
Dorzolamide hydrochloride is a carbonic anhydrase inhibitor primarily used in the treatment of elevated intraocular pressure in conditions such as glaucoma and ocular hypertension. It is a white to off-white crystalline powder that is soluble in water and exhibits a pH range typically between 4.5 and 6.5 when dissolved. The substance works by inhibiting the enzyme carbonic anhydrase, which reduces the production of aqueous humor in the eye, thereby lowering intraocular pressure. Dorzolamide hydrochloride is often administered as an eye drop solution, and its pharmacokinetics indicate that it has a relatively short half-life, necessitating multiple daily doses for effective management of eye pressure. The compound is generally well-tolerated, though some patients may experience local ocular side effects such as burning or stinging upon application. As with any medication, it is important to consider contraindications and potential interactions with other drugs.
Formula:C10H17ClN2O4S3
InChI:InChI=1/C10H16N2O4S3.ClH/c1-3-12-8-4-6(2)18(13,14)10-7(8)5-9(17-10)19(11,15)16;/h5-6,8,12H,3-4H2,1-2H3,(H2,11,15,16);1H/t6-,8-;/m0./s1
SMILES:CCN[C@H]1C[C@H](C)S(=O)(=O)c2c1cc(s2)S(=O)(=O)N.Cl
Synonyms:
  • 3-B)Thiopyran-2-Sulfonamide,5,6-Dihydro-4-(Ethylamino)-6-Methyl-4H-Thieno(
  • Mk-0507
  • Monohydrochloride,(4S-Trans)-7-Dioxide
  • (2S,4S)-2-Ethylamino-4-Methyl-5,5-Dioxo-5,7-Dithiabicyclo[4.3.0]Nona-8,10-Diene-8-Sulfonamide Hydrochloride
  • Dorzolamide Hcl
  • Dorzolamide Hydrochloride
  • DorzolomideHcl,Usp
  • (4S,6S)-4-(ethylamino)-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide hydrochloride
  • Dorzalamide hydrochloride
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Found 1 products.
  • rac-trans Dorzolamide Hydrochloride
    TRC
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    rac-trans Dorzolamide Hydrochloride

    Controlled Product
    CAS:
    <p>Applications rac-trans Dorzolamide is an impurity of Dorzolamide (D535100).<br>References Casini, A., et al.: Bioorg. Med. Chem. Lett., 13, 841 (2003), Clare, B., et al.: Bioorg. Med. Chem., 13, 2197 (2005),<br></p>
    Formula:C10H17ClN2O4S3
    Color and Shape:Neat
    Molecular weight:360.9

    Ref: TR-D535120

    5mg
    254.00€
    50mg
    1,964.00€