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CAS 120279-96-1

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Dorzolamide

Description:
Dorzolamide is a carbonic anhydrase inhibitor primarily used in the treatment of elevated intraocular pressure in conditions such as glaucoma and ocular hypertension. It is a sulfonamide derivative, characterized by its ability to inhibit the enzyme carbonic anhydrase, which plays a crucial role in the production of aqueous humor in the eye. The chemical formula of dorzolamide is C10H16N2O4S, and it has a molecular weight of approximately 224.31 g/mol. This compound is typically administered as a topical ophthalmic solution, allowing for localized action with minimal systemic absorption. Dorzolamide is known for its relatively low solubility in water, which can affect its formulation and delivery. Common side effects may include ocular discomfort, taste disturbances, and allergic reactions. Its mechanism of action involves reducing bicarbonate secretion, leading to decreased fluid production in the eye, thereby lowering intraocular pressure. Overall, dorzolamide is an important therapeutic agent in managing certain eye conditions, contributing to better patient outcomes in ocular health.
Formula:C10H16N2O4S3
InChI:InChI=1S/C10H16N2O4S3/c1-3-12-8-4-6(2)18(13,14)10-7(8)5-9(17-10)19(11,15)16/h5-6,8,12H,3-4H2,1-2H3,(H2,11,15,16)/t6-,8-/m0/s1
InChI key:InChIKey=IAVUPMFITXYVAF-XPUUQOCRSA-N
SMILES:O=S1(=O)C2=C([C@@H](NCC)C[C@@H]1C)C=C(S(N)(=O)=O)S2
Synonyms:
  • (2R,4R)-2-Ethylamino-4-Methyl-5,5-Dioxo-5,7-Dithiabicyclo[4.3.0]Nona-8,10-Diene-8-Sulfonamide
  • (4R,6R)-4-(ethylamino)-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide
  • (4S,6S)-4-(Ethylamino)-5,6-dihydro-6-methyl-4H-thieno-[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide
  • (4S,6S)-4-(ethylamino)-5,6-dihydro-6-methyl-7,
  • (4S,6S)-4-(ethylamino)-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide
  • 4-(ethylamino)-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide
  • 4H-Thieno[2,3-b]thiopyran-2-sulfonamide, 4-(ethylamino)-5,6-dihydro-6-methyl-, 7,7-dioxide, (4R-cis)-
  • 4H-Thieno[2,3-b]thiopyran-2-sulfonamide, 4-(ethylamino)-5,6-dihydro-6-methyl-, 7,7-dioxide, (4S,6S)-
  • 4H-Thieno[2,3-b]thiopyran-2-sulfonamide, 4-(ethylamino)-5,6-dihydro-6-methyl-, 7,7-dioxide, (4S-cis)-
  • 4H-Thieno[2,3-b]thiopyran-2-sulfonamide, 4-(ethylamino)-5,6-dihydro-6-methyl-, 7,7-dioxide, (4S-trans)-
  • See more synonyms
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