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CAS 120398-66-5

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PERINDOPRIL ACYL-B-D-GLUCURONIDE

Description:
Perindopril acyl-β-D-glucuronide is a chemical compound that serves as a metabolite of the angiotensin-converting enzyme (ACE) inhibitor perindopril. It is characterized by its glucuronidation, a process where a glucuronic acid moiety is conjugated to the parent drug, enhancing its solubility and facilitating excretion. This compound typically exhibits properties associated with its parent drug, including antihypertensive effects, but may also have distinct pharmacokinetic and pharmacodynamic profiles. The presence of the glucuronide moiety can influence its bioavailability, duration of action, and potential side effects. As a metabolite, it is often studied in the context of drug metabolism and pharmacokinetics to understand how perindopril is processed in the body. The compound is generally soluble in water due to its polar nature, and its stability can be affected by pH and temperature. Understanding the characteristics of perindopril acyl-β-D-glucuronide is essential for evaluating the overall therapeutic efficacy and safety of perindopril in clinical settings.
Formula:C25H40N2O11
InChI:InChI=1/C25H40N2O11/c1-4-8-14(23(34)36-5-2)26-12(3)21(31)27-15-10-7-6-9-13(15)11-16(27)24(35)38-25-19(30)17(28)18(29)20(37-25)22(32)33/h12-20,25-26,28-30H,4-11H2,1-3H3,(H,32,33)/t12-,13-,14-,15-,16?,17?,18?,19?,20?,25?/m0/s1
SMILES:CCC[C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@H]2CCCC[C@H]2CC1C(=O)OC1C(C(C(C(C(=O)O)O1)O)O)O
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