CAS 120410-24-4

Biapenem

Description:

Biapenem is a broad-spectrum carbapenem antibiotic, primarily used for the treatment of various bacterial infections. It exhibits a high degree of stability against many beta-lactamases, making it effective against a wide range of Gram-positive and Gram-negative bacteria, including some strains resistant to other antibiotics. Biapenem works by inhibiting bacterial cell wall synthesis, leading to cell lysis and death. It is typically administered intravenously and is known for its favorable pharmacokinetic profile, including good tissue penetration and a relatively short half-life. The compound is generally well-tolerated, but like other antibiotics, it may cause side effects such as gastrointestinal disturbances or allergic reactions. Biapenem is particularly valuable in clinical settings for treating complicated infections, including those caused by multi-drug resistant organisms. Its use is often guided by susceptibility testing to ensure effectiveness against the specific pathogens involved in an infection. As with all antibiotics, appropriate use is crucial to minimize the development of resistance.

Formula: C₁₅H₁₈N₄O₄S

InChI: InChI=1S/C15H18N4O4S/c1-7-11-10(8(2)20)14(21)19(11)12(15(22)23)13(7)24-9-3-17-5-16-6-18(17)4-9/h5-11,20H,3-4H2,1-2H3/t7-,8-,10-,11-/m1/s1

InChI key: InChIKey=MRMBZHPJVKCOMA-YJFSRANCSA-N

SMILES: C([O-])(=O)C=1N2[C@@]([C@@]([C@@H](C)O)(C2=O)[H])([C@@H](C)C1SC3CN4[N+](C3)=CN=C4)[H]

Synonyms:

• (4R,5S,6S)-3-(6,7-dihydro-5H-pyrazolo[1,2-a][1,2,4]triazol-4-ium-6-ylsulfanyl)-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate
• 1-Azabicyclo[3.2.0]heptane, 5H-pyrazolo[1,2-a][1,2,4]triazol-4-ium deriv.
• 5H-Pyrazolo[1,2-a][1,2,4]triazol-4-ium, 6-[[(4R,5S,6S)-2-carboxy-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-en-3-yl]thio]-6,7-dihydro-, inner salt
• 5H-Pyrazolo[1,2-a][1,2,4]triazol-4-ium, 6-[[2-carboxy-6-(1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-en-3-yl]thio]-6,7-dihydro-, inner salt, [4R-[4α,5β,6β(R*)]]-
• 6-({(4R,5S,6S)-2-carboxy-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-en-3-yl}sulfanyl)-6,7-dihydro-5H-pyrazolo[1,2-a][1,2,4]triazol-4-ium
• 6-[[(4R,5S,6S)-2-Carboxy-6-[(1R)-1-Hydroxyethyl]-4-Methyl-7-Oxo-1-Azabicyclo[3.2.0]Hept-2-En-3-Yl]Thio]-6,7-Dihydro-5H-Pyrazolo[1,2-A][1,2,4]Triazol-4-Ium Inner Salt
• 6-[[(4R,5S,6S)-2-Carboxy-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-en-3-yl]thio]-6,7-dihydro-5H-pyrazolo[1,2-a]-s-triazol-4-ium hydroxide, inner salt
• Biapenern
• Cl 186-815
• Cl 186815
• L 627
• Ljc 10627

Biapenem

CAS: 120410-24-4

Formula: C₁₅H₁₈N₄O₄S

Purity: >98.0%(HPLC)

Color and Shape: White to Light yellow to Light orange powder to crystal

Molecular weight: 350.39

Ref: 3B-B5522

5H-Pyrazolo[1,2-a][1,2,4]triazol-4-ium, 6-[[(4R,5S,6S)-2-carboxy-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-en-3-yl]thio]-6,7-dihydro-, inner salt

CAS: 120410-24-4

Formula: C₁₅H₁₈N₄O₄S

Purity: 98%

Color and Shape: Solid

Molecular weight: 350.3928

Ref: IN-DA0034IP

(4R,5S,6S)-3-((6,7-Dihydro-5H-Pyrazolo[1,2-A][1,2,4]Triazol-4-Ium-6-Yl)Thio)-6-((R)-1-Hydroxyethyl)-4-Methyl-7-Oxo-1-Azabicyclo[3.2.0]Hept-2-Ene-2-Carboxylate

CAS: 120410-24-4

(4R,5S,6S)-3-((6,7-Dihydro-5H-Pyrazolo[1,2-A][1,2,4]Triazol-4-Ium-6-Yl)Thio)-6-((R)-1-Hydroxyethyl)-4-Methyl-7-Oxo-1-Azabicyclo[3.2.0]Hept-2-Ene-2-Carboxylate

Purity: 98%

Molecular weight: 350.39g/mol

Ref: 54-OR1008222

Biapenem

CAS: 120410-24-4

Formula: C₁₅H₁₈N₄O₄S

Purity: ≥ 98.0%

Color and Shape: White to off-white crystalline powder

Molecular weight: 350.39

Ref: 7W-GA6808

Biapenem

CAS: 120410-24-4

Biapenem

Purity: ≥95%

Molecular weight: 350.39g/mol

Ref: 54-BUP11365

Biapenem-13C2,15N2

CAS: 120410-24-4

Formula: C₁₃₁₃C₂H₁₈N₂₁₅N₂O₄S

Molecular weight: 354.36

Ref: 4Z-B-081019

Biapenem

CAS: 120410-24-4

Formula: C₁₅H₁₈N₄O₄S

Molecular weight: 350.39

Ref: 4Z-B-081017

Biapenem-13C2,15N3

CAS: 120410-24-4

Formula: C₁₃₁₃C₂H₁₈N₁₅N₃O₄S

Molecular weight: 355.36

Ref: 4Z-B-081018

Biapenem-15N3

CAS: 120410-24-4

Formula: C₁₅H₁₈N₁₅N₃O₄S

Molecular weight: 353.37

Ref: 4Z-B-081020

Biapenem

CAS: 120410-24-4

Biapenem (CLI 86815), a carbapenem antibiotic, has broad antibacterial effects, stable kidney enzyme resistance, and low neurotoxicity.

Formula: C₁₅H₁₈N₄O₄S

Purity: 97.92% - 99.57%

Color and Shape: White To Light Yellow Powder

Molecular weight: 350.39

Ref: TM-T6411

Biapenem

Controlled Product

CAS: 120410-24-4

Applications An carbapenem antibacterial.
References Shigemi, A., et al.: Int. J. Antimicrob. Agents, 34, 589 (2009), Miguet, L., et al.: J. Med. Chem., 52, 5926 (2009), Zhao, W., et al.: J. Med. Microbiol., 58, 1080 (2009), Sanbongi, Y., et al.: Microbiol. Immunol., 53, 361 (2009),

Formula: C₁₅H₁₈N₄O₄S

Color and Shape: Neat

Molecular weight: 350.39

Ref: TR-B372800

Biapenem

CAS: 120410-24-4

Biapenem is a carbapenem antibiotic and is used for the treatment of bacterial infections. It inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins.

Formula: C₁₅H₁₈N₄O₄S

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 350.39 g/mol

Ref: 3D-AC18581