CAS 120443-16-5

Verlukast

Description:

Verlukast, with the CAS number 120443-16-5, is a chemical compound that belongs to the class of leukotriene receptor antagonists. It is primarily utilized in the treatment of asthma and allergic rhinitis by inhibiting the action of leukotrienes, which are inflammatory mediators that contribute to bronchoconstriction and mucus production. The compound is characterized by its ability to selectively block the cysteinyl leukotriene receptor, thereby reducing airway inflammation and improving respiratory function. Verlukast is typically administered orally and is known for its favorable pharmacokinetic profile, including good bioavailability and a relatively long half-life, which allows for once-daily dosing. Its safety profile is generally well-tolerated, with common side effects being mild and transient. As with other medications in its class, it is important for patients to consult healthcare professionals for appropriate use and potential interactions with other medications. Overall, Verlukast represents a valuable option in the management of respiratory conditions associated with leukotriene activity.

Formula: C₂₆H₂₇ClN₂O₃S₂

InChI: InChI=1/C26H27ClN2O3S2/c1-29(2)24(30)12-14-33-26(34-15-13-25(31)32)20-5-3-4-18(16-20)6-10-22-11-8-19-7-9-21(27)17-23(19)28-22/h3-11,16-17,26H,12-15H2,1-2H3,(H,31,32)/b10-6+

Synonyms:

• Verlukast [USAN:INN]
• 3-(((alphaR)-m-((E)-2-(7-Chloro-2-quinolyl)vinyl)-alpha-((2-(dimethylcarbamoyl)ethyl)thio)benzyl)thio)propionic acid
• L 668,019
• Mk 679
• Propanoic acid, 3-(((3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)((3-(dimethylamino)-3-oxopropyl)thio)methyl)thio)-, (R-(E))-
• Unii-5Q9O54P0H7
• Verlukastum
• Verlukastum [INN-Latin]

Verlukast

Controlled Product

CAS: 120443-16-5

Applications A receptor antagonist for the treatment of respiratory diseases.
References Morgenstern, R., et al.: Biochem. J., 260, 577 (1989), Armstrong, R., et al.: Chem. Res. Toxicol., 10, 2 (1997), Larsen, J., et al.: Ann. Allergy, 71, 103 (1993),

Formula: C₂₆H₂₇ClN₂O₃S₂

Color and Shape: Neat

Molecular weight: 515.09

Ref: TR-V128500

Verlukast

CAS: 120443-16-5

Leukotriene D4 antagonist

Formula: C₂₆H₂₇ClN₂O₃S₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 515.09 g/mol

Ref: 3D-FV28691

Verlukast

CAS: 120443-16-5

Verlukast (MK-0679) is a selective, orally active leukotriene D4 receptor antagonist for use in bronchial asthma research.

Formula: C₂₆H₂₇ClN₂O₃S₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 515.09

Ref: TM-T19674