CAS 120443-30-3

(-)-Carbovir

Description:

(-)-Carbovir, with the CAS number 120443-30-3, is a synthetic nucleoside analog that exhibits antiviral properties, particularly against retroviruses such as HIV. It is characterized by its structure, which includes a modified sugar moiety and a purine base, allowing it to interfere with viral replication. As a prodrug, (-)-Carbovir is phosphorylated intracellularly to its active triphosphate form, which then competes with natural nucleotides for incorporation into viral DNA during reverse transcription. This incorporation leads to chain termination, effectively inhibiting viral proliferation. The compound is known for its selectivity and potency, making it a candidate for therapeutic applications in the treatment of HIV/AIDS. Additionally, (-)-Carbovir has been studied for its pharmacokinetic properties, including absorption, distribution, metabolism, and excretion, which are crucial for its efficacy and safety profile. Its stereochemistry, denoted by the prefix "(-)", indicates its specific optical activity, which is significant in the context of biological interactions and drug design.

Formula: C₁₁H₁₃N₅O₂

InChI: InChI=1S/C11H13N5O2/c12-11-14-9-8(10(18)15-11)13-5-16(9)7-2-1-6(3-7)4-17/h1-2,5-7,17H,3-4H2,(H3,12,14,15,18)/t6-,7+/m1/s1

InChI key: InChIKey=XSSYCIGJYCVRRK-RQJHMYQMSA-N

SMILES: O=C1C2=C(N(C=N2)[C@@H]3C[C@H](CO)C=C3)NC(N)=N1

Synonyms:

• (-)-Carbovir
• 2-Amino-1,9-dihydro-9-[(1R,4S)-4-(hydroxymethyl)-2-cyclopenten-1-yl]-6H-purin-6-one
• 6H-Purin-6-one,2-amino-1,9-dihydro-9-[4-(hydroxymethyl)-2-cyclopenten-1-yl]-, (1R-cis)-
• 6H-Purin-6-one, 2-amino-1,9-dihydro-9-[(1R,4S)-4-(hydroxymethyl)-2-cyclopenten-1-yl]-

(-)-Carbovir

CAS: 120443-30-3

Color and Shape: Neat

Ref: 86-MM3249.20

(-)-Carbovir

CAS: 120443-30-3

Applications (-)-Carbovir, is a nucleoside/nucleotide reverse transcriptase inhibitor (NRTI) caused mitochondrial toxicity in human hepatoma carcinoma cell.
References Suo, Z., et al.: J. Biol. Chem., 273, 27250 (1998), Ray, A., et al.: Antimicrob. Agents Chemother., 48, 1089 (2004), Lynx, M., et al.: Biochem. Pharmacol., 71, 1342 (2006),

Formula: C₁₁H₁₃N₅O₂

Color and Shape: Neat

Molecular weight: 247.2532

Ref: TR-C177685

(-)-Carbovir

CAS: 120443-30-3

(-)-Carbovir is a synthetic nucleoside reverse transcriptase inhibitor (NRTI), which is derived from the enantiomerically pure isomer of carbocyclic 2'-deoxyguanosine. As an antiviral agent, its mode of action involves the inhibition of the reverse transcriptase enzyme, crucial for the replication of retroviruses, including HIV. By competing with natural nucleosides, (-)-Carbovir gets incorporated into viral DNA, causing chain termination and preventing further replication of the virus.

Formula: C₁₁H₁₃N₅O₂

Purity: Min. 95%

Molecular weight: 247.25 g/mol

Ref: 3D-VEA44330

Carbovir

CAS: 120443-30-3

Carbovir, an NRTI, induces mitochondrial toxicity in human liver cancer cells.

Formula: C₁₁H₁₃N₅O₂

Color and Shape: Solid

Molecular weight: 247.25

Ref: TM-T71241