CAS 1204669-58-8: Epacadostat

Description:Epacadostat, with the CAS number 1204669-58-8, is a small molecule inhibitor primarily known for its role in immunotherapy, particularly in cancer treatment. It functions as an inhibitor of the enzyme indoleamine 2,3-dioxygenase 1 (IDO1), which is involved in the catabolism of the amino acid tryptophan. By inhibiting IDO1, Epacadostat aims to enhance the immune response against tumors by preventing the local depletion of tryptophan and the accumulation of immunosuppressive metabolites. This mechanism can potentially restore T-cell function and promote anti-tumor immunity. Epacadostat has been investigated in combination with other therapies, such as checkpoint inhibitors, to improve therapeutic outcomes in various malignancies. The compound is characterized by its specific molecular structure, which allows it to selectively target IDO1, and it is typically administered orally. As with many investigational drugs, its safety and efficacy are evaluated through clinical trials, and ongoing research continues to explore its potential applications in oncology.

Formula:C₁₁H₁₃BrFN₇O₄S

InChI:InChI=1S/C11H13BrFN7O4S/c12-7-5-6(1-2-8(7)13)17-11(18-21)9-10(20-24-19-9)15-3-4-16-25(14,22)23/h1-2,5,16,21H,3-4H2,(H,15,20)(H,17,18)(H2,14,22,23)

InChI key:InChIKey=FBKMWOJEPMPVTQ-UHFFFAOYSA-N

SMILES:O=S(=O)(N)NCCNC1=NON=C1C(=NO)NC2=CC=C(F)C(Br)=C2

Found 5 products.

Product data	Purity	Price range	Estimated delivery
(Z)-N-(3-bromo-4-fluorophenyl)-N'-hydroxy-4-[2-(sulfamoylamino)ethylamino]-1,2,5-oxadiazole-3-carboxamidine REF: IN-DA008TM7CAS: 1204669-58-8	99%	To inquire	Fri 11 Apr 25
Epacadostat REF: TM-T3548CAS: 1204669-58-8	100% - 99.93%	47.00 €~1,035.00 €	Mon 21 Apr 25
Epacadostat REF: 7W-GW6692CAS: 1204669-58-8	- - -	223.00 €~686.00 €	Mon 21 Apr 25
Epacadostat REF: 3D-FA103715CAS: 1204669-58-8	Min. 95%	222.00 €~650.00 €	Tue 22 Apr 25
Epacadostat REF: TR-E565503CAS: 1204669-58-8	- - -	102.00 €~958.00 €	Thu 22 May 25