CAS 1204669-58-8

Epacadostat

Description:

Epacadostat, with the CAS number 1204669-58-8, is a small molecule inhibitor primarily known for its role in immunotherapy, particularly in cancer treatment. It functions as an inhibitor of the enzyme indoleamine 2,3-dioxygenase 1 (IDO1), which is involved in the catabolism of the amino acid tryptophan. By inhibiting IDO1, Epacadostat aims to enhance the immune response against tumors by preventing the local depletion of tryptophan and the accumulation of immunosuppressive metabolites. This mechanism can potentially restore T-cell function and promote anti-tumor immunity. Epacadostat has been investigated in combination with other therapies, such as checkpoint inhibitors, to improve therapeutic outcomes in various malignancies. The compound is characterized by its specific molecular structure, which allows it to selectively target IDO1, and it is typically administered orally. As with many investigational drugs, its safety and efficacy are evaluated through clinical trials, and ongoing research continues to explore its potential applications in oncology.

Formula: C₁₁H₁₃BrFN₇O₄S

InChI: InChI=1S/C11H13BrFN7O4S/c12-7-5-6(1-2-8(7)13)17-11(18-21)9-10(20-24-19-9)15-3-4-16-25(14,22)23/h1-2,5,16,21H,3-4H2,(H,15,20)(H,17,18)(H2,14,22,23)

InChI key: InChIKey=FBKMWOJEPMPVTQ-UHFFFAOYSA-N

SMILES: C(\NC1=CC(Br)=C(F)C=C1)(=N\O)/C=2C(NCCNS(N)(=O)=O)=NON2

Synonyms:

• ICBN 24360
• Epacadostat
• 1,2,5-Oxadiazole-3-carboximidamide, 4-[[2-[(aminosulfonyl)amino]ethyl]amino]-N-(3-bromo-4-fluorophenyl)-N′-hydroxy-, [C(Z)]-
• [C(Z)]-4-[[2-[(Aminosulfonyl)amino]ethyl]amino]-N-(3-bromo-4-fluorophenyl)-N′-hydroxy-1,2,5-oxadiazole-3-carboximidamide
• INCB 024360
• Epacadostat (INCB24360, INCB024360)
• INCB-24360(INCB-024360)
• INCB 024360 ， Epacadostat
• (Z)-N-(3-bromo-4-fluorophenyl)-N'-hydroxy-4-[2-(sulfamoylamino)ethylamino]-1,2,5-oxadiazole-3-carboxamidine
• (Z)-N-(3-bromo-4-fluorophenyl)-N'-hydroxy-4-((2-(sulfamoylamino)ethyl)amino)-1,2,5-oxadiazole-3-carboximidamide
• N-(3-Bromo-4-fluoro-phenyl)-N'-hydroxy-4-[2-(sulfamoylamino)ethylamino]-1,2,5-oxadiazole-3-carboxamidine
• (1204669-37-3)
• Epacadostat(INCN024360)
• INCB024360;INCB-024360;INCB 024360
• Epacadostat(INCB024360)
• CS-1617
• INCN024360
• IDO inhibitor(INCB024360)

(Z)-N-(3-Bromo-4-fluorophenyl)-N'-hydroxy-4-[2-(sulfamoylamino)ethylamino]-1,2,5-oxadiazole-3-carboxamidine

CAS: 1204669-58-8

Formula: C₁₁H₁₃BrFN₇O₄S

Purity: 98%

Color and Shape: Solid

Molecular weight: 438.2328

Ref: IN-DA008TM7

Epacadostat

CAS: 1204669-58-8

Epacadostat

Purity: ≥95%

Molecular weight: 438.23g/mol

Ref: 54-BUP17721

Epacadostat

CAS: 1204669-58-8

Epacadostat (INCB 024360) is an oral, potent and selective IDO1 inhibitor with IC50 value of 71.8 nM.Cost-effective and quality-assured.

Formula: C₁₁H₁₃BrFN₇O₄S

Purity: 98% - >99.99%

Color and Shape: Solid

Molecular weight: 438.23

Ref: TM-T3548

Epacadostat

CAS: 1204669-58-8

Ref: 7W-GW6692

Epacadostat

CAS: 1204669-58-8

Inhibitor of dioxygenase IDO1

Formula: C₁₁H₁₃BrFN₇O₄S

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 438.23 g/mol

Ref: 3D-FA103715

Epacadostat

CAS: 1204669-58-8

Purity: 99%

Molecular weight: 438.23

Ref: 10-F979248

Epacadostat

Controlled Product

CAS: 1204669-58-8

Applications Epacadostat is a potent and novel indoleamine 2,3-dioxygenase (IDO1) inhibitor with IC50 of 10 nM. It has high selectivity over IDO2 and tryptophan 2,3-dioxygenase (TDO).
References Yue, Eddy W., et al.: ACS Med. Chem. Lett., 8, 486 (2017);

Formula: C₁₁H₁₃BrFN₇O₄S

Color and Shape: Neat

Molecular weight: 438.23

Ref: TR-E565503