CAS 120511-73-1

Anastrozole

Description:

Anastrozole is a non-steroidal aromatase inhibitor primarily used in the treatment of hormone receptor-positive breast cancer in postmenopausal women. Its mechanism of action involves the inhibition of the aromatase enzyme, which is responsible for converting androgens into estrogens, thereby reducing estrogen levels in the body. This reduction is crucial as many breast cancers are fueled by estrogen. Anastrozole is typically administered orally and is known for its favorable pharmacokinetic profile, including good absorption and a relatively long half-life, allowing for once-daily dosing. Common side effects may include hot flashes, joint pain, and fatigue, among others. The substance is classified as a prescription medication and is often part of adjuvant therapy following surgery or radiation. Anastrozole is recognized for its effectiveness in improving disease-free survival rates in breast cancer patients, making it a significant option in oncological pharmacotherapy. Its chemical structure features a triazole ring, contributing to its specificity and efficacy as an aromatase inhibitor.

Formula: C₁₇H₁₉N₅

InChI: InChI=1S/C17H19N5/c1-16(2,9-18)14-5-13(8-22-12-20-11-21-22)6-15(7-14)17(3,4)10-19/h5-7,11-12H,8H2,1-4H3

InChI key: InChIKey=YBBLVLTVTVSKRW-UHFFFAOYSA-N

SMILES: C(C#N)(C)(C)C1=CC(C(C#N)(C)C)=CC(CN2C=NC=N2)=C1

Synonyms:

• 1,3-Benzenediacetonitrile, α¹,α¹,α³,α³-tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-
• 1,3-Benzenediacetonitrile,Alpha,Alpha,Alpha',Alpha'-Tetramethyl-5-(1H-1,2,4-Triazol-1-Ylmethyl)-
• 1,3-Benzenediacetonitrile,a,a,a',a'-tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl)
• 1-[3,5-Di-(1-Methyl-1-Cyano)-Ethyl]-Benzyl-1,2,4-Triazole
• 2,2'-[5-(1H-1,2,4-triazol-1-ylmethyl)benzene-1,3-diyl]bis(2-methylpropanenitrile)
• 2,2′-[5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-phenylene]di(2-methylpropionitrile)
• 2-[3-(1-Cyano-1-methylethyl)-5-[(1H-1,2,4-triazol-1-yl)methyl]phenyl]-2-methylpropanenitrile
• 2-[3-(2-Cyano-2-propyl)-5-(1,2,4-triazol-1-ylmethyl)phenyl]-2-methylpropiononitrile
• 2-[3-(2-Cyanopropan-2-yl)-5-(1,2,4-triazol-1-ylmethyl)phenyl]-2-methylpropanenitrile
• Anastrazole
• Anastrol
• Anastrozol
• Anatrozole
• Arimidex
• Ici-D-1033
• Tetramethyl-5-(1H-1,2,4-Triazol-1Ylmethyl) 1,3-Benzenediacetionitrile
• Tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-benzenediacetionitrile
• ZD-1033, ICI-D-1033, Arimidex
• Zd
• Zd-1033
• α¹,α¹,α³,α³-Tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-benzenediacetonitrile
• Anastrozole
• 1,3-Benzenediacetonitrile, α1,α1,α3,α3-tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-
• 1,3-benzenediacetonitrile, alpha,alpha,alpha',alpha'-tetramethyl- 5-(1h-1,2,4-triazol-1-ylmethyl)-
• zd

Anastrozole

CAS: 120511-73-1

Formula: C₁₇H₁₉N₅

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 293.37

Ref: 3B-A2370

Anastrozole

CAS: 120511-73-1

Color and Shape: Neat

Ref: 61-FOR1250.00

Anastrozole

CAS: 120511-73-1

Anastrozole

Formula: C₁₇H₁₉N₅

Purity: 99.7%

Color and Shape: White

Molecular weight: 293.16405

Ref: 47-1213

ANASTROZOLE CRS

CAS: 120511-73-1

ANASTROZOLE CRS

Formula: C₁₇H₁₉N₅

Molecular weight: 293.3663

Ref: 41-Y0001522

Anastrozole

CAS: 120511-73-1

Aromatic or modified aromatic drugs with nitrogen heter

Formula: C₁₇H₁₉N₅

Color and Shape: Off-White Powder

Molecular weight: 293.16405

Ref: 45-1034807

Anastrozole

CAS: 120511-73-1

Anastrozole (ZD1033)(ZD1033), a potent and highly selective aromatase (CYP19) inhibitor (IC50 = 15 nM), has no obvious effect on adrenocorticoid hormone

Formula: C₁₇H₁₉N₅

Purity: 99.73% - 99.84%

Color and Shape: Crystalline Solid

Molecular weight: 293.37

Ref: TM-T0393

Anastrozole

CAS: 120511-73-1

Formula: C₁₇H₁₉N₅

Color and Shape: White To Off-White Solid

Molecular weight: 293.37

Ref: 4Z-A-241

Anastrozole

Controlled Product

CAS: 120511-73-1

Formula: C₁₇H₁₉N₅

Color and Shape: Neat

Molecular weight: 293.37

Ref: 04-C10248750

Anastrozole

Controlled Product

CAS: 120511-73-1

Formula: C₁₇H₁₉N₅

Color and Shape: Neat

Molecular weight: 293.37

Ref: 86-MM1250.00

Anastrozole

CAS: 120511-73-1

Formula: C₁₇H₁₉N₅

Purity: ≥ 98.0%

Color and Shape: White to beige powder or crystals

Molecular weight: 293.37

Ref: 7W-GP2172

Anastrozole RS

CAS: 120511-73-1

Color and Shape: White Solid Powder Or Crystalline Powder

Ref: 2K-1007500021

Anastrozole

Controlled Product

CAS: 120511-73-1

Applications An aromatase inhibitor. Used as an antineoplastic.
References Plourde, P.V., et al.: Breast Cancer Res. Treat., 30, 103 (1994), Buzdar, A.U., et al.: Cancer, 79, 730 (1997)

Formula: C₁₇H₁₉N₅

Color and Shape: Neat

Molecular weight: 293.37

Ref: TR-A637425

Anastrozole - Bio-X ™

Controlled Product

CAS: 120511-73-1

Anastrozole is a non-steroidal drug that belongs to the class of aromatase inhibitors. It inhibits the production of estrogen by blocking the conversion of androgens to estrogens in peripheral tissues. The drug has been shown to be effective in treating breast cancer in postmenopausal women. In vitro assays have shown that Anastrozole can inhibit tumor growth as well as induce apoptosis in human serum cells, which suggests that it may be effective against a variety of cancers.

Formula: C₁₇H₁₉N₅

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 293.37 g/mol

Ref: 3D-BT164176

Anastrozole

Controlled Product

CAS: 120511-73-1

Inhibits aromatase (CYP19) enzyme; antineoplastic

Formula: C₁₇H₁₉N₅

Purity: Min. 98 Area-%

Color and Shape: White Powder

Molecular weight: 293.37 g/mol

Ref: 3D-FT10600