CAS 120570-05-0

(3S)-1-azabicyclo[2.2.2]octan-3-amine

Description:

(3S)-1-azabicyclo[2.2.2]octan-3-amine, also known as quinuclidin-3-amine, is a bicyclic organic compound characterized by its unique bicyclic structure that includes a nitrogen atom within the ring system. This compound features a tertiary amine functional group, which contributes to its basicity and potential reactivity. The stereochemistry at the 3-position, indicated by the (3S) designation, suggests that it has specific spatial arrangements that can influence its biological activity and interactions with receptors. This compound is of interest in medicinal chemistry, particularly in the development of pharmaceuticals targeting the central nervous system, due to its ability to interact with neurotransmitter systems. Its structural properties allow for potential applications in drug design, particularly as a scaffold for creating compounds with desired pharmacological effects. Additionally, the bicyclic nature of the molecule may confer stability and specificity in its interactions, making it a valuable compound for further research in various chemical and biological contexts.

Formula: C₇H₁₄N₂

InChI: InChI=1/C7H14N2/c8-7-5-9-3-1-6(7)2-4-9/h6-7H,1-5,8H2/t7-/m1/s1

SMILES: C1CN2CCC1[C@@H](C2)N

Synonyms:

• (3S)-Quinuclidin-3-amine
• (S)-Quinuclidin-3-amine
• 1-Azabicyclo[2.2.2]octan-3-amine, (3S)-
• T66 A B CNTJ AZ & & S Form
• (3S)-1-Azabicyclo[2.2.2]octan-3-amine

(S)-quinuclidin-3-amine

CAS: 120570-05-0

Formula: C₇H₁₄N₂

Purity: 95%

Color and Shape: Solid

Molecular weight: 126.1995

Ref: IN-DA007PUN

(S)-quinuclidin-3-amine

CAS: 120570-05-0

(S)-quinuclidin-3-amine

Purity: 95%

Molecular weight: 126.203g/mol

Ref: 54-OR73324

(S)-quinuclidin-3-amine

CAS: 120570-05-0

Purity: 95%

Molecular weight: 126.2

Ref: 10-F787767

(3S)-Aminoquinuclidine

Controlled Product

CAS: 120570-05-0

Applications (3S)-Aminoquinuclidine is an intermediate used in the synthesis of Palonosetron-3-ene Hydrochloride (P165825), which is an impurity of Palonosetron (P165800), a serotonin 5-HT3 receptor antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). Antiemetic.
References Clark, R.D., et al.: J. Med. Chem., 36, 2645 (1993); Wong, E.H.F., et al.: Br. J. Pharmacol., 114, 851 (1995); Grunberg, S.M., et al.: Expert. Opin. Pharmacother., 4, 2297 (2003); Eisenberg, P., et al.: Ann. Oncol., 15, 330 (2004); Siddiqui, M.A.A., et al.: Drugs, 64, 1125 (2004)

Formula: C₇H₁₄N₂

Color and Shape: Neat

Molecular weight: 126.2

Ref: TR-A628775