CAS 120595-80-4

P-acetamidophenyl B-D-glucuronide*sodium

Description:

P-acetamidophenyl B-D-glucuronide sodium, with the CAS number 120595-80-4, is a chemical compound that serves as a glucuronide conjugate of p-acetamidophenol (commonly known as acetaminophen). This compound is characterized by its structure, which includes a phenolic moiety linked to a glucuronic acid unit, facilitating its solubility and excretion in biological systems. The sodium salt form enhances its stability and solubility in aqueous solutions, making it suitable for various biochemical applications. It is often studied in the context of drug metabolism, as glucuronidation is a key phase II metabolic pathway that aids in detoxifying and eliminating drugs and xenobiotics from the body. The compound may exhibit low toxicity and is generally considered safe for use in research settings. Its properties, such as solubility, stability, and reactivity, make it a valuable tool in pharmacological studies, particularly in understanding the metabolism of acetaminophen and related compounds.

Formula: C₁₄H₁₆NNaO₈

InChI: InChI=1/C14H17NO8.Na/c1-6(16)15-7-2-4-8(5-3-7)22-14-11(19)9(17)10(18)12(23-14)13(20)21;/h2-5,9-12,14,17-19H,1H3,(H,15,16)(H,20,21);/q;+1/p-1/t9-,10-,11+,12-,14-;/m1./s1

SMILES: CC(=Nc1ccc(cc1)OC1C(C(C(C(C(=O)O)O1)O)O)O)O.[Na]

Synonyms:

• p-Acetamidophenyl beta-D-glucuronide
• sodium (2R,3R,4R,5S,6S)-6-(4-acetamidophenoxy)-3,4,5-trihydroxy-tetrahydropyran-2-carboxylate

Acetaminophen Glucuronide Sodium Salt (Paracetamol Glucuronide Sodium Salt)

CAS: 120595-80-4

Formula: C₁₄H₁₆NO₈·Na

Color and Shape: Off-White To Pale Yellow Solid

Molecular weight: 326.28 22.99

Ref: 4Z-A-0210

4-Acetamidophenyl β-D-glucuronide, sodium salt

CAS: 120595-80-4

4-Acetamidophenyl β-D-glucuronide, sodium salt

Purity: ≥95%

Molecular weight: 349.27g/mol

Ref: 54-OR5850T

Acetaminophen Glucuronide sodium salt

CAS: 120595-80-4

Acetaminophen Glucuronide sodium salt (APAP-glu) is a compound with antipyretic and analgesic activity and potential nephrotoxicity.

Formula: C₁₄H₁₆NNaO₈

Color and Shape: Off-White Cyrstalline Solid

Molecular weight: 349.27

Ref: TM-T36826

Acetaminophen-O-β-D-glucuronide, sodium salt

CAS: 120595-80-4

Acetaminophen-O-β-D-glucuronide, sodium salt

Purity: >98%

Molecular weight: 349.27g/mol

Ref: 54-BICL4004

p-Acetamidophenyl β-D-glucuronide sodium salt

CAS: 120595-80-4

Formula: C₁₄H₁₆NO₈Na

Molecular weight: 349.27

Ref: 7W-GC9506

4-Acetamidophenyl β-D-Glucuronide Sodium Salt

Controlled Product

CAS: 120595-80-4

Stability Hygroscopic
Applications 4-Acetamidophenyl β-D-Glucuronide is a major urinary metabolite of Acetaminophen (A161220) (Paracetamol) in human (1). Acetaminophen is an analgesic and antipyretic agent and used as a pain reliever to treat headache, muscle aches, and arthritis (2,3).
References (1) Johnston, D., et al.: J. Chem. Res., Synop., 12, 406 (1988)(2) McGill, M. R. and Jaeschke, H. Pharm Res. 30, 2174 (2013)(3) Fairbrother, J.E., et al.: Anal. Profiles Drug Subs., 3, 1 (1974)

Formula: C₁₄H₁₆NO₈·Na

Color and Shape: White To Light Red

Molecular weight: 349.27

Ref: TR-A158500

4-Acetamidophenyl b-D-glucuronide sodium salt

CAS: 120595-80-4

4-Acetamidophenyl b-D-glucuronide sodium salt is a pharmaceutical drug that is a metabolite of acetaminophen. It can be detected in the urine by biochips, which are microarrays that contain immobilized binding sites for specific analytes. The analysis of 4-acetamidophenyl b-D-glucuronide sodium salt in urine is used to screen for the use of acetaminophen and to identify cytochrome P450 2C19 (CYP2C19) activity. This drug can also be detected by spectrometric methods using biochemical assays on plates or hepatocytes and mass spectrometric detection methods using liquid chromatography/mass spectrometry (LC/MS). Acetaminophen has been shown to have toxic effects on the liver, kidneys, and lungs in humans, as well as on diode photoluminescence.

Formula: C₁₄H₁₆NNaO₈

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 349.27 g/mol

Ref: 3D-MA04458