CAS 1206161-97-8: Filgotinib
Description:Filgotinib is a small molecule drug primarily classified as a Janus kinase (JAK) inhibitor, specifically targeting JAK1. It is designed for the treatment of autoimmune diseases, including rheumatoid arthritis and inflammatory bowel disease. The compound exhibits a selective mechanism of action, which helps to minimize off-target effects commonly associated with broader JAK inhibitors. Filgotinib is characterized by its oral bioavailability and a favorable pharmacokinetic profile, allowing for once-daily dosing. Its chemical structure includes a pyrimidine core, contributing to its potency and selectivity. The drug has undergone extensive clinical trials to evaluate its efficacy and safety, demonstrating significant improvements in disease activity among patients. As with many JAK inhibitors, potential side effects may include increased risk of infections and changes in blood parameters, necessitating careful monitoring during treatment. Overall, Filgotinib represents a targeted therapeutic option in the management of chronic inflammatory conditions.
Formula:C21H23N5O3S
InChI:InChI=1S/C21H23N5O3S/c27-20(17-8-9-17)23-21-22-19-3-1-2-18(26(19)24-21)16-6-4-15(5-7-16)14-25-10-12-30(28,29)13-11-25/h1-7,17H,8-14H2,(H,23,24,27)
InChI key:InChIKey=RIJLVEAXPNLDTC-UHFFFAOYSA-N
SMILES:O=C(NC=1N=C2C=CC=C(C=3C=CC(=CC3)CN4CCS(=O)(=O)CC4)N2N1)C5CC5
- Synonyms:
- N-[5-[4-[(1,1-Dioxido-4-thiomorpholinyl)methyl]phenyl][1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamide
- N-(5-(4-((1,1-Dioxidothiomorpholino)methyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl)cyclopropanecarboxamide
- filgotinib (GLPG0634)
- G 146034
- GLPG 0634
- Cyclopropanecarboxamide, N-[5-[4-[(1,1-dioxido-4-thiomorpholinyl)methyl]phenyl][1,2,4]triazolo[1,5-a]pyridin-2-yl]-
- CyclopropanecarboxaMide, N-[5-[4-[(1,1-dioxido-4-thioMorpholinyl)Methyl]phenyl][1,2,4]triazolo[1,5-a]pyridin-2-yl]-
- Filgotinib
- N-[5-[4-[(1,1-Dioxido-4-thiomorpholinyl)methyl]phenyl][1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamide
- See more synonyms
- SYN1158