CAS 1206161-97-8: Filgotinib

Description: Filgotinib is a small molecule drug primarily classified as a Janus kinase (JAK) inhibitor, specifically targeting JAK1. It is designed for the treatment of autoimmune diseases, including rheumatoid arthritis and inflammatory bowel disease. The compound exhibits a selective mechanism of action, which helps to minimize off-target effects commonly associated with broader JAK inhibitors. Filgotinib is characterized by its oral bioavailability and a favorable pharmacokinetic profile, allowing for once-daily dosing. Its chemical structure includes a pyrimidine core, contributing to its potency and selectivity. The drug has undergone extensive clinical trials to evaluate its efficacy and safety, demonstrating significant improvements in disease activity among patients. As with many JAK inhibitors, potential side effects may include increased risk of infections and changes in blood parameters, necessitating careful monitoring during treatment. Overall, Filgotinib represents a targeted therapeutic option in the management of chronic inflammatory conditions.

Formula: C₂₁H₂₃N₅O₃S

InChI: InChI=1S/C21H23N5O3S/c27-20(17-8-9-17)23-21-22-19-3-1-2-18(26(19)24-21)16-6-4-15(5-7-16)14-25-10-12-30(28,29)13-11-25/h1-7,17H,8-14H2,(H,23,24,27)

InChI key: InChIKey=RIJLVEAXPNLDTC-UHFFFAOYSA-N

SMILES: O=C(NC=1N=C2C=CC=C(C=3C=CC(=CC3)CN4CCS(=O)(=O)CC4)N2N1)C5CC5

Synonyms:

• N-[5-[4-[(1,1-Dioxido-4-thiomorpholinyl)methyl]phenyl][1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamide
• N-(5-(4-((1,1-Dioxidothiomorpholino)methyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl)cyclopropanecarboxamide
• filgotinib (GLPG0634)
• G 146034
• GLPG 0634
• Cyclopropanecarboxamide, N-[5-[4-[(1,1-dioxido-4-thiomorpholinyl)methyl]phenyl][1,2,4]triazolo[1,5-a]pyridin-2-yl]-
• CyclopropanecarboxaMide, N-[5-[4-[(1,1-dioxido-4-thioMorpholinyl)Methyl]phenyl][1,2,4]triazolo[1,5-a]pyridin-2-yl]-
• Filgotinib
• N-[5-[4-[(1,1-Dioxido-4-thiomorpholinyl)methyl]phenyl][1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamide
• SYN1158

N-[5-[4-[(1,1-Dioxido-4-thiomorpholinyl)methyl]phenyl][1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamide

CAS: 1206161-97-8

• Formula: C₂₁H₂₃N₅O₃S
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 425.504

Filgotinib

CAS: 1206161-97-8

• Purity: 98.02%
• Molecular weight: 425.5g/mol

Filgotinib

CAS: 1206161-97-8

• Molecular weight: 425.50g/mol

Filgotinib

CAS: 1206161-97-8

• Formula: C₂₁H₃₅N₅O₃S
• Color and Shape: White To Off-White Solid
• Molecular weight: 425.51

GLPG0634

CAS: 1206161-97-8

Filgotinib

CAS: 1206161-97-8

Filgotinib (GLPG0634) is a selective JAK1 inhibitor. The IC50 values against JAK1, JAK2, JAK3, and …

• Formula: C₂₁H₂₃N₅O₃S
• Purity: 98.03% - ≥95%
• Color and Shape: Solid
• Molecular weight: 425.5

GLPG-0634 (Filgotinib)

CAS: 1206161-97-8

Applications GLPG-0634 (Filgotinib) is a potent, selective JAK1 inhibitor. Used as an anti-inflammatory agent, it …

• Formula: C₂₁H₂₃N₅O₃S
• Color and Shape: Neat
• Molecular weight: 425.5

Filgotinib

CAS: 1206161-97-8

Please enquire for more information about Filgotinib including the price, delivery time and more detailed …

• Formula: C₂₁H₂₃N₅O₃S
• Purity: Min. 95%
• Molecular weight: 425.51 g/mol