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Filgotinib

CAS 1206161-97-8: Filgotinib

Description:Filgotinib is a small molecule drug primarily classified as a Janus kinase (JAK) inhibitor, specifically targeting JAK1. It is designed for the treatment of autoimmune diseases, including rheumatoid arthritis and inflammatory bowel disease. The compound exhibits a selective mechanism of action, which helps to minimize off-target effects commonly associated with broader JAK inhibitors. Filgotinib is characterized by its oral bioavailability and a favorable pharmacokinetic profile, allowing for once-daily dosing. Its chemical structure includes a pyrimidine core, contributing to its potency and selectivity. The drug has undergone extensive clinical trials to evaluate its efficacy and safety, demonstrating significant improvements in disease activity among patients. As with many JAK inhibitors, potential side effects may include increased risk of infections and changes in blood parameters, necessitating careful monitoring during treatment. Overall, Filgotinib represents a targeted therapeutic option in the management of chronic inflammatory conditions.

Formula:C21H23N5O3S

InChI:InChI=1S/C21H23N5O3S/c27-20(17-8-9-17)23-21-22-19-3-1-2-18(26(19)24-21)16-6-4-15(5-7-16)14-25-10-12-30(28,29)13-11-25/h1-7,17H,8-14H2,(H,23,24,27)

InChI key:InChIKey=RIJLVEAXPNLDTC-UHFFFAOYSA-N

SMILES:O=C(NC=1N=C2C=CC=C(C=3C=CC(=CC3)CN4CCS(=O)(=O)CC4)N2N1)C5CC5

  • Synonyms:
  • N-[5-[4-[(1,1-Dioxido-4-thiomorpholinyl)methyl]phenyl][1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamide
  • N-(5-(4-((1,1-Dioxidothiomorpholino)methyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl)cyclopropanecarboxamide
  • filgotinib (GLPG0634)
  • G 146034
  • GLPG 0634
  • Cyclopropanecarboxamide, N-[5-[4-[(1,1-dioxido-4-thiomorpholinyl)methyl]phenyl][1,2,4]triazolo[1,5-a]pyridin-2-yl]-
  • CyclopropanecarboxaMide, N-[5-[4-[(1,1-dioxido-4-thioMorpholinyl)Methyl]phenyl][1,2,4]triazolo[1,5-a]pyridin-2-yl]-
  • Filgotinib
  • N-[5-[4-[(1,1-Dioxido-4-thiomorpholinyl)methyl]phenyl][1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamide
  • See more synonyms
  • SYN1158
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N-[5-[4-[(1,1-Dioxido-4-thiomorpholinyl)methyl]phenyl][1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamide

CAS:1206161-97-8

Ref: IN-DA0039FK

1g472.00 €
5gTo inquire
1mg38.00 €
5mg43.00 €
10mg49.00 €
25mg60.00 €
50mg83.00 €
100mg102.00 €
250mg146.00 €
500mg189.00 €
Estimated delivery in United States, on Monday 10 Mar 2025
discount label

Filgotinib

CAS:1206161-97-8

Ref: 54-BISN0129

1g631.00 €
5g1,718.00 €
1mg37.00 €
5mg50.00 €
10mg64.00 €
25mg85.00 €
50mg116.00 €
100mg179.00 €
250mg264.00 €
Estimated delivery in United States, on Tuesday 11 Mar 2025
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Filgotinib

CAS:1206161-97-8

Ref: 4Z-F-142001

5mgTo inquire
10mgTo inquire
25mgTo inquire
50mgTo inquire
100mgTo inquire
Estimated delivery in United States, on Tuesday 11 Mar 2025
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GLPG0634

CAS:1206161-97-8

Ref: 7W-GW4741

1mg506.00 €
5mg796.00 €
10mg1,132.00 €
Estimated delivery in United States, on Monday 17 Mar 2025
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Filgotinib

CAS:1206161-97-8

Ref: TM-T1929

1mg39.00 €
5mg78.00 €
10mg110.00 €
25mg163.00 €
50mg250.00 €
100mg329.00 €
1mL*10mM (DMSO)78.00 €
Estimated delivery in United States, on Monday 17 Mar 2025
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GLPG-0634 (Filgotinib)

Controlled Product
CAS:1206161-97-8

Ref: TR-G411100

5mg204.00 €
10mg311.00 €
25mg468.00 €
Estimated delivery in United States, on Tuesday 18 Mar 2025
discount label

Filgotinib

CAS:1206161-97-8

Ref: 3D-BF159062

25mg342.00 €
50mg457.00 €
100mg724.00 €
250mg942.00 €
500mg1,227.00 €
Estimated delivery in United States, on Monday 21 Apr 2025
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